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Toxicological information

Carcinogenicity

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Administrative data

Description of key information

The main phase of Si/FeSi silicate consists of practically insoluble silicates. No carcinogenic crystalline silica or fibrous silicates have been detected in Si/FeSi silicate samples. Therefore, read-across to other silicates and silica is necessary.
IARC (1997) has evaluated silica as not classifiable as a carcinogen, and OECD SIDS (2004) concludes that the “cancerogenic potential of synthetic amorphous silicas/silicates can be considered as negligible”.

Key value for chemical safety assessment

Justification for classification or non-classification

Si/FeSi silicate is not classificable for carcinogenicity.

Additional information

No carcinogenicity data of Si/FeSi silicate exists. The main phase of Si/FeSi silicate consists of practically insoluble silicates. No carcinogenic crystalline silica or fibrous silicates have been detected in Si/FeSi silicate samples. The bioavailable form of synthetic amorphous silica and silicates is the dissolved form which exists as monosilicic acid. It is assumed that a similar effects profile for them exists.

The animal studies of amorphous silicas or non-fibrous silicates have not shown carcinogenic activity. Human data from occupational exposures to amorphous silica or clay-like silicates like kaolin or bentonite have not shown an increased cancer risk from inhalation of these materials. Similar experience also exists for workers in the silicon/ferroalloys industry, where there is a risk of exposure to Si/FeSi silicate.

IARC (1997) has evaluated silica as not classifiable as a carcinogen and OECD SIDS (2004) concludes that the “cancerogenic potential of synthetic amorphous silicas/silicates can be considered as negligible”.