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EC number: 231-548-0 | CAS number: 7631-90-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
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- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
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- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
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- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: human data
- Adequacy of study:
- supporting study
- Study period:
- no data available
- Reliability:
- other: not rated acc. to Klimisch
- Rationale for reliability incl. deficiencies:
- other: Any kind of reliability rating is not considered to be applicable, since human studies/reports are not conducted/reported according to standardised guidelines.
Data source
Reference
- Reference Type:
- publication
- Title:
- Contact dermatitis due to ammonium bisulfite in a bleaching cream
- Author:
- Pambor, M.
- Year:
- 1 996
- Bibliographic source:
- Contact Derm., 35, 48-49
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- patch test
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium hydrogensulfite
- EC Number:
- 231-548-0
- EC Name:
- Sodium hydrogensulfite
- Cas Number:
- 7631-90-5
- Molecular formula:
- NaHSO3
- IUPAC Name:
- sodium hydrogensulfite
- Details on test material:
- - Name of test material (as cited in study report): sodium bisulfite
No further details are given.
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 1
- Sex: female
- Age: 44 years
No further details are given. - Clinical history:
- - Symptoms, onset and progress of the disease: The woman had previous seborrhoeic eczema (1988) and idiopathic urticaria (1992) presented in 1994.
- Exposure history: For several months, she had used a bleaching cream containing 0.45% ammonium bisulfite. 2 days prior to presentation, she had repeated the procedure of bleaching her eyebrows and developed a dermatitis related to the use of this cream, with secondary spread to the ears.
- Aggravating factors both in home and workplace:
With cessation of contact and therapy with topical corticosteroids, ther dermatitis improved. - Controls:
- 6 control, not further specified
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test):
The woman was patch tested with a standard series (Hermal), the bleaching cream and its individual ingredients. In addition, patch tests were performed with sodium bisulfite (sodium hydrogen sulfite).
ADMINISTRATION
- Type of application: occlusive: 1 day
- Description of patch: The tests were carried out using Finn Chambers and Scanpore tape.
- Vehicle / solvent: water
- Concentrations: 0.45% aq. and 0.1% aq for ammonium bisulfite and 1.0% aq, 0.45% aq and 0.1% aq for sodium bisulfite
- Testing/scoring schedule: Readings were made 1, 2, 3 and 7 days after application.
EXAMINATIONS
No further details are given.
Results and discussion
- Results of examinations:
- SYMPTOMS
- Frequency, level, duration of symptoms observed: see table below
OTHER RESULTS:
Only ammonium bisulfite and sodium bisulfite gave positive reactions in the patient.
Any other information on results incl. tables
Patch test preparation | Results | ||||
Day 1 | Day 2 | Day 3 | Day 7 | ||
ammonium bisulfite | 0.45% aq. 0.1% aq. |
+ + |
+++ +++ |
+++ +++ |
+ + |
sodium bisulfite | 1.0% aq. 0.45% aq. 0.1% aq. |
++ - - |
+++ +++ +++ |
+++ +++ +++ |
+ + + |
Applicant's summary and conclusion
- Conclusions:
- In a standard patch test in one patient, who sufferd from contact dermatitis due to sulfites in a bleaching cream, only ammonium bisulfite and sodium bisulfite gave positive reactions in the patient.
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