Registration Dossier
Registration Dossier
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EC number: 265-996-3 | CAS number: 65996-65-8 The product of agglomerating iron ore fines, concentrates, iron sinter, and other iron-bearing materials. Includes pellets, nodules and briquettes.
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: Human health surveillance
- Adequacy of study:
- supporting study
- Study period:
- March 1970 - October 1973
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Occupational screening.
Data source
Reference
- Reference Type:
- publication
- Title:
- Radiological abnormalities in electric-arc welders
- Author:
- Attfield MD, Ross DS
- Year:
- 1 978
- Bibliographic source:
- Br J Ind Med 35(2): 117-122
Materials and methods
- Study type:
- medical screening
- Remarks:
- Chest X-rays
- Endpoint addressed:
- repeated dose toxicity: inhalation
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Iron
- EC Number:
- 231-096-4
- EC Name:
- Iron
- Cas Number:
- 7439-89-6
- Molecular formula:
- Fe
- IUPAC Name:
- iron(2+)
- Details on test material:
- - Name of test material (as cited in study report): Iron dust
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Details on study design:
- Six hundred and sixty-one currently employed electric arc welders and twelve retired electric arc welders at a United Kingdom company had chest X-rays taken between 1970 and 1973. Study team doctors examined the X-rays for radiological abnormalities. The X-ray scores were analyzed, giving percentages of workers with small rounded opacities of score 0/1 or greater.
Results and discussion
- Results:
- There was no evidence of large opacities in any of the X-rays. About 8% (7.9%) of the welders had x-rays of grade 0/1 or higher, showing evidence of small, rounded opacities. However, more than 50% had only an ILO score of 0/1. Abnormalities other than large or small opacities were recorded, and the most common of those was tuberculosis. The prevalence of small opacities increased as the length of employment as a welder increased. There were no signs of abnormalities until fifteen years of exposure had passed, after which the prevalence of opacities continues to increase.
Applicant's summary and conclusion
- Conclusions:
- Long-term (>15 years) exposure to iron and other dusts shows an increased risk of small opacities in chest X-rays.
- Executive summary:
A group of 661 electric arc welders in the United Kingdom had chest x-rays between 1970 and 1973. These x-rays were scored by three doctors for signs of abnormalities. Only 8% of the X-rays scored showed abnormalities of 0/1 or greater (more than 50% of these only 0/1). The risk of abnormality increased with increasing length of employment. There were few signs of severe abnormalities in these workers.
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