Sodium acetate

Eye irritation

Administrative data

Endpoint:

eye irritation

Remarks:

other: read-across from in vivo experimental test with an analogue

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The analogue Potassium Acetate which shares the same functional group with Sodium Acetate, also has comparable values for the relevant molecular properties for the eye irritation endpoint.

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other:

Title:

Unnamed

Year:

2010

Materials and methods

Principles of method if other than guideline:

Read-across approach from Letter of Access experimental data (test method similar to OECD 405) on the analogue Potassium Acetate.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Potassium acetate

EC Number:

204-822-2

EC Name:

Potassium acetate

Cas Number:

127-08-2

IUPAC Name:

potassium acetate

Details on test material:

- Name of test material (as cited in study report): Potassium acetate
- Molecular formula (if other than submission substance): C2H4O2.K
- Molecular weight (if other than submission substance): 98.142
- Smiles notation (if other than submission substance): [K+].[O-]C(C)=O
- InChl (if other than submission substance): 1/C2H4O2.K/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
- Structural formula attached as image file (if other than submission substance): see Fig. in attached report
- Analytical purity: 50,1% Potassium acetate
- Impurities (identity and concentrations): 0,10% Tolyltriazol; 0,05% H3PO4; rest water till 100%.
- Purity test date: 1990-07-16
- Lot/batch No.: Hoe CG 0255 OA ZD50 0001
- Storage condition of test material: 20 ºC (in dark)

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

cornea opacity score

Basis:

mean

Time point:

other: 72 h

Score:

0

Max. score:

4

Results 2

Irritation parameter:

iris score

Basis:

mean

Time point:

other: 72 h

Score:

0

Max. score:

2

Results 3

Irritation parameter:

conjunctivae score

Basis:

mean

Time point:

other: 72 h

Score:

1

Max. score:

3

Other effects:

Based on the experimental results obtained with the analogue Potassium Acetate, which is considered to be not irritating for New Zealand White rabbits eyes, and applying the read-across approach, the substance Sodium Acetate is also considered as not irritating under test conditions.

The analogue Potassium Acetate which shares the same functional group with Sodium Acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is -3.72 for Potassium Acetate and for Sodium Acetate,
- a similar water solubility which is 2.5 g/mL at 20 ºC for Potassium Acetate and 1.25 g/mL for Sodium Acetate at 25 ºC, and
- similar molecular weights which are 98.14 for Potassium Acetate and 82.03 for Sodium Acetate.

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The substance Sodium Acetate is considered as not irritating under test conditions.

Executive summary:

Based on the experimental results (reported under the endpoint record 07.03.02_02 KAc) obtained with the analogue Potassium Acetate, which is considered to be not irritating for New Zealand White rabbits eyes, and applying the read-across approach, the substance Sodium acetate is also considered as not irritating under test conditions.