Sodium acetate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The analogue Calcium Acetate which shares the same functional group with Sodium Acetate, also has comparable values for the relevant molecular properties for the acute inhalation toxicity endpoint.

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other: read-across

Title:

Unnamed

Year:

2010

Materials and methods

Principles of method if other than guideline:

Read-across approach from Letter of Access experimental data (study with a test method similar to OECD 403) on the analogue Calcium Acetate.

GLP compliance:

no

Test type:

other: read-across from an standard acute method with an analogue

Test material

Test material information

Constituent 1

Reference substance name:

Calcium di(acetate)

EC Number:

200-540-9

EC Name:

Calcium di(acetate)

Cas Number:

62-54-4

IUPAC Name:

calcium diacetate

Constituent 2

Reference substance name:

calcium acetate

IUPAC Name:

calcium acetate

Details on test material:

- Name of test material (as cited in study report): calcium di(acetate)
- Physical state: firmly, white powder
- Molecular formula (if other than submission substance): C2H4O2.1/2Ca
- Molecular weight (if other than submission substance): 158.166
- Smiles notation (if other than submission substance): [Ca+2].[O-]C(C)=O.[O-]C(C)=O
- InChl (if other than submission substance): InChI=1/2C2H4O2.Ca/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2
- Structural formula attached as image file (if other than submission substance): see Fig. in attached report

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LC50

Effect level:

> 5.81 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Other findings:

Based on the experimental results obtained with the analogue Calcium Acetate (LC 50 for female rats > 5.6 mg/L air) and the molecular weights, the read-across approach is applied and the LC50 for substance Sodium Acetate is calculated to be higher than 5.81 mg/L air under test conditions.

The analogue Calcium Acetate, which shares the same functional group with Sodium Acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is - 1.38 for Calcium Acetate and -3.72 for Sodium Acetate,
- a similar water solubility which is 1.0 g/mL at 25 ºC for Calcium Acetate and 1.25 g/mL for Sodium Acetate at 25 ºC, and
- molecular weights which are 158.166 for Calcium Acetate and 82.03 for Sodium Acetate.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LC50 for substance Sodium Acetate is calculated to be higher than 5.81 mg/L air under test conditions.

Executive summary:

Based on the experimental results (reported under the endpoint record 07.02.02_02 CaAc) obtained with the analogue Calcium Acetate (LC 50 for female rats > 5.6 mg/L air) and the molecular weights, the read-across approach is applied and the LC50 for substance Sodium Acetate is calculated to be higher than 5.81 mg/L air under test conditions.