Sodium acetate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The analogue Potassium Acetate which shares the same functional group with Sodium Acetate, also has comparable values for the relevant molecular properties for the acute oral toxicity endpoint.

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other: read-across

Title:

Unnamed

Year:

2010

Materials and methods

Principles of method if other than guideline:

Read-across approach from published experimental data (non-standard method) on the analogue Potassium Acetate.

GLP compliance:

no

Test type:

other: read-across from a non-standard study with an analogue

Test material

Test material information

Constituent 1

Reference substance name:

Potassium acetate

EC Number:

204-822-2

EC Name:

Potassium acetate

Cas Number:

127-08-2

IUPAC Name:

potassium acetate

Details on test material:

- Name of test material (as cited in study report): Potassium acetate
- Molecular formula (if other than submission substance): C2H4O2.K
- Molecular weight (if other than submission substance): 98.142
- Smiles notation (if other than submission substance): [K+].[O-]C(C)=O
- InChl (if other than submission substance): 1/C2H4O2.K/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
- Structural formula attached as image file (if other than submission substance): see Fig. in attached report

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

2.72 other: g/kg bw

Based on:

test mat.

95% CL:

2.07 - 3.56

Other findings:

Based on the experimental results obtained with the analogue Potassium Acetate (LD 50 for male rats = 3.25 (2.48-4.26) g/kg) and the molecular weights, the read-across approach is applied and the LD50 for substance Sodium Acetate is calculated to be 2.72 (2.07-3.56) g/kg.

The analogue Potassium Acetate which shares the same functional group with Sodium Acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is -3.72 for Potassium Acetate and for Sodium Acetate,
- a similar water solubility which is 2.5 g/mL at 20 ºC for Potassium Acetate and 1.25 g/mL for Sodium Acetate at 25 ºC, and
- similar molecular weights which are 98.14 for Potassium Acetate and 82.03 for Sodium Acetate.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LD50 for substance Sodium Acetate is calculated to be 2.72 (2.07-3.56) g/kg bw.

Executive summary:

Based on the experimental results obtained (reported under the endpoint record 07.02.01_05 KAc) with the analogue Potassium Acetate (LD 50 for male rats = 3.25 (2.48-4.26) g/kg) and the molecular weights, the read-across approach is applied and the LD50 for substance Sodium Acetate is calculated to be 2.72 (2.07-3.56) g/kg bw.