Sodium acetate

Endpoint summary

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

2 720 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Dose descriptor:

LC50

Value:

5 810 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion

Dose descriptor:

LD50

Value:

28 269.15 mg/kg bw

Additional information

Based on the experimental results obtained (reported under the endpoint record 07.02.01_05 KAc) with the analogue Potassium Acetate (LD 50 for male rats = 3.25 (2.48-4.26) g/kg) and the molecular weights, the read-across approach is applied and the LD50 for substance Sodium Acetate is calculated to be 2.72 (2.07-3.56) g/kg bw.

Based on the experimental results (reported under the endpoint record 07.02.02_02 CaAc) obtained with the analogue Calcium Acetate (LC 50 for female rats > 5.6 mg/L air) and the molecular weights, the read-across approach is applied and the LC50 for substance Sodium Acetate is calculated to be higher than 5.81 mg/L air under test conditions.

Based on the experimental results (reported under the endpoint record 07.02.03_02 Fumaric Acid) obtained with the analogue Fumaric Acid (LD 50 for New Zealand rabbits > 20000 mg/kg bw) and the molecular weights, the read-across approach is applied and the LD 50 for substance Sodium Acetate is calculated to be greater than 28269.15 mg/kg bw under test conditions.

Justification for classification or non-classification

Acute toxicity:

Oral: LC50>2000mg/kg bw: non- classification

Dermal: LC50>2000mg/kg bw: non- classification

Inhalation: LC50>5 mg/L: non-classification