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EC number: 265-148-2 | CAS number: 64742-46-7 A complex combination of hydrocarbons obtained by treating a petroleum fraction with hydrogen in the presence of a catalyst. It consists of hydrocarbons having carbon numbers predominantly in the range of C11 through C25 and boiling in the range of approximately 205°C to 400°C (401°F to 752°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute Oral Toxicity:
The acute oral LD50 for other gas oils is > 5000 mg/kg of bodyweight in male and female rats, based on no mortality and minimal signs of toxicity (OECD 401).
Acute Inhalation Toxicity:
The acute inhalation LC50 for other gas oils for both male and female rats is 4.6 mg/L (aerosol) (OECD 403). This is supported by a further study in which a hydrodesulphurised middle distillate gave an LC50 of 7.64 mg/L (aerosol). In addition a read-across study with a straight run gas oil gave an LC50 of >2.53 mg/l
Acute Dermal Toxicity:
The acute dermal LD50 for other gas oils is > 2000mg/kg body weight for male and female rabbits, based on no mortality or evidence of adverse effects (OECD 402).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- One of two studies carried out simultaneously on different samples of CAS 64742-80-9
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 4 600 mg/m³ air
- Quality of whole database:
- One of two studies carried out simultaneously on different samples of 64741-44-2. Also similar results in a read across study with a straight run gas oil
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- One of two studies carried out simultaneously on different samples of CAS 64742-80-9
Additional information
Acute Oral Toxicity:
The key acute oral toxicity studies investigated the effects of hydrodesulfurised middle distillate (Klimisch scores = 2, API 1982a,b). Fasted Sprague Dawley rats (5 male/5 female) were administered a single oral dose of >5000 mg/kg body weight via gavage. After 14 days of observation, no mortality or abnormal changes in body weight were observed in any of the rats. At necropsy, two mildly enlarged cervical lymph nodes, a distended stomach, moderately dilated renal pelvis, and alopecia on the stomach area and red exudate and severe corneal ulcerations in the eyes were found. The acute oral LD50 was > 5000 mg/kg body weight. A similar result was seen in a supporting study with another sample of the same material.
Acute Inhalation Toxicity
For acute inhalation toxicity, the key study investigated the effects of hydrodesulfurised middle distillate in male and female Sprague Dawley rats exposed (whole body) to aerosol concentrations in the range of 0 - 7.3 mg/L for 4 hours (Klimisch score = 2, API 1983a). There were no reported mortalities during the 4hr exposure period, deaths occurring during the 14 day post-exposure observation period. Macroscopic and microscopic findings were limited to the lungs, where moderate to severe pulmonary irritation was apparent. Based on these results the LC50 for both males and females is 4.6 mg/L (aerosol) for other gas oils.
Additional data exist on the acute inhalation of other gas oils (API, 1983). This information on a hydrodesulfurised middle distillate aerosol is presented in the dossier. It had an LC50 of 7.64 mg/L, which is higher than the limit for classification.
In a supporting read-across acute inhalation toxicity study (EMBSI, 1991), a sample of a straight run gas oil (CAS no. 64741-44-2) was administered to Sprague-Dawley rats (5/sex/dose) via inhalation (in air; nose only) at a concentration of 2.53 mg/L for a period of 4 hours. The four hour acute inhalation LC50 for the test material was determined to be greater than 2.53 mg/L.
Acute Dermal Toxicity
The key acute dermal toxicity studies investigated the effects of hydrodesulfurised middle distillate at a dose of 2000 mg/kg body weight for 24 hours on male and female rabbits (Klimisch scores = 1, API 1982a,b). Animals were observed for 14 days post-exposure. Neither study reported mortality in the study, and only slight skin irritation. A similar result was seen in a supporting study with another sample of the same material.
Based on results, the LD50 for other gas oils is >2000 mg/kg body weight.Justification for classification or non-classification
Other Gas Oils are not classified for acute oral or dermal toxicity based on the LD50 values, which are greater than the criteria for classification defined in the EU CLP Regulation (EC No. 1272/2008).
Other Gas Oils are classified as harmful by inhalation (H332) based on a conservative read-across study showing an LC50 of > 2.53 mg/L (mist - mixed aerosol and vapour) for male and female rats seen with straight-run gas oils, according to the EU CLP Regulation (EC No. 1272/2008).
Regulatory classification and labelling for aspiration toxicity relies on the measured or calculated kinematic viscosity of a substance at 40°C rather than results from toxicological studies with animals. Hydrocarbons with kinematic viscosities ≤20.5 mms/sec are classified for aspiration toxicity (H304) according to EU CLP criteria. As members of this category exist as low viscosity liquids that meet these criteria, substances in this category are classified for aspiration hazard. Other Gas Oils are classified as aspiration hazards (H304).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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