Registration Dossier

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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment.

Data source

Reference
Reference Type:
publication
Title:
Toxicity of Nickel Sulphate.
Author:
Kosova, L.V.
Year:
1979
Bibliographic source:
Gig. Tr. Prof. Zabol. 23:48-49. (H&SE Translation No. 10640).

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Year: 1979 (unclear if "Year of test guideline" or "Year of study completion".)
GLP compliance:
not specified
Test type:
other: not reported
Limit test:
no

Test material

Constituent 1
Reference substance name:
Nickel sulphate hexahydrate
IUPAC Name:
Nickel sulphate hexahydrate
Constituent 2
Chemical structure
Reference substance name:
Nickel sulphate
EC Number:
232-104-9
EC Name:
Nickel sulphate
Cas Number:
7786-81-4
Molecular formula:
NiSO4
IUPAC Name:
nickel(2+) sulfate

Test animals

Species:
rat

Administration / exposure

Type of coverage:
not specified
Duration of exposure:
30 days
Doses:
50% aqueous solution applied daily for 30 days.

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
500 other: mg NiSO4.6H2O/kg
Remarks on result:
other: as reported in the 2005 Nickel Sulphate Risk Assessment
Gross pathology:
No systems pathology found was observed from a 50% aqueous solution applied daily for 30 days.

Applicant's summary and conclusion

Executive summary:

STUDY RATED BY AN INDEPENDENT REVIEWER.

ROBUST SUMMARY DEVELOPED BY AN INDEPENDENT REVIEWER.

Robust Summary of Kosova 1979:


No systems pathology found was observed from a 50% aqueous solution applied daily for 30 days.

Results from other studies:

A 5% aqueous solution of nickel sulphate proved to be an irritant in some individuals when applied to the back under occlusion (Kalimo, K. and  

K. Lammintausta.  1984.  24 and 48 hour allergen exposure in patch testing. Contact Dermatit. 10:25-29.).

On the unoccluded human forearm, with the nickel sulphate solution being applied once daily for three days, the threshold concentration of  

aqueous nickel sulphate producing irritation was 20% (Frosch, P.J. and A.M. Kligman.  1976.  The chamber scarification test for irritancy.   

Contact Dermatit.  2:314-324.).