Registration Dossier
Registration Dossier
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EC number: 266-028-2 | CAS number: 65996-93-2 The residue from the distillation of high temperature coal tar. A black solid with an approximate softening point from 30°C to 180°C (86°F to 356°F). Composed primarily of a complex mixture of three or more membered condensed ring aromatic hydrocarbons.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 June - 03 July 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Pitch, coal tar, high-temp.
- EC Number:
- 266-028-2
- EC Name:
- Pitch, coal tar, high-temp.
- Cas Number:
- 65996-93-2
- Molecular formula:
- not applicable
- IUPAC Name:
- Pitch, coal tar, high-temp.
- Test material form:
- solid: particulate/powder
- Details on test material:
- Electrode binder [CAS No. 65996-93-2]
- Name of test material (as cited in study report): 101.110
- Substance type: organic
Constituent 1
- Specific details on test material used for the study:
- Electrode binder [CAS No. 65996-93-2]
- Name of test material (as cited in study report): 101.110
- Physical state: solid, black powder
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga, Sulzfeld/Germany
- Age at study initiation: no data
- Weight at study initiation: 180.0 - 200.0 g (m); 151.9 - 181.9 g (f)
- Fasting period before study: 16 h
- Housing: max. 5/cage
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: >= 7 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +-2 °C
- Humidity (%): 50 - 85
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50 % (w/v)
- Amount of vehicle (if gavage): The TS was applied in a constant volume of 5-% carboxymethylcellulose.
- Justification for choice of vehicle: inert carrier material for suspending insoluble solids
MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg bw
- Rationale for the selection of the limit dose: The dose was derived from a range-finding test and corresponded to the maximally applicable volume. - Doses:
- 15000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: day 0 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopic organpathology - Statistics:
- not applicable
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 15 000 mg/kg bw
- Mortality:
- none
- Clinical signs:
- other: none
- Gross pathology:
- no particular findings
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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