Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

In accordance with Column 2 of REACH Annex VII, the skin sensitisation study (Section 8.3) does not need to be conducted because the substance is corrosive.

Due to the hydrochloric acid related corrosivity of parent compound titanium tetrachloride and target compound titanium oxychloride, no data valid data for the classification of skin sensitising potential is available. No reports on skin sensitisation of humans after occupational exposure are available. On the contrary titanium dioxide, which would be the finally resulting stable compound after completion of the hydrolysis reaction, clearly is not a sensitiser. Based on these considerations, target chemical titanium oxychloride is being regarded not to be a sensitiser.


Migrated from Short description of key information:
The sensitization potential of titanium oxychloride is not accessible due to hydrochloric acid related corrosivity in aqueous solutions.

Justification for classification or non-classification

The sensitization potential of titanium oxychloride is not accessible due to hydrochloric acid related corrosivity in watery solutions. Hydrolysis product titanium oxychloride is deemed not to be a sensitiser and correspondingly does not need to be classified according to CLP/GHS.