Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Short term toxicity to invertebrates - OECD 202 – EC50: 70.7 mg/l, 48h - (PARAD consortium, NOACK, 2010, M. Noack)

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
70.7 mg/L

Additional information

Short term toxicity to invertebrates - OECD 202 – EC50: 70.7 mg/l, 48h - (PARAD consortium, NOACK, 2010, M. Noack)

In an acute immobilization test withDaphnia magna(STRAUS) the effects of the test item (batch number:S700040031) were determined according to OECD 202 (2004) and Council Regulation (EC) No. 440/2008 Method C.2 (2008) from2010-05-17 to 2010-06-09atDr.U.Noack-Laboratorien, Käthe-Paulus-Straße 1, D-31157 Sarstedt, Germany.

The study was conducted under static conditions with 5 concentration levels of the test item ranging from 6.25 to 100 mg/L set up in a geometrical series with a dilution factor of 2 over a period of 48 h. 20 test organisms were exposed to each test concentration and the control.
All concentration levels and the control were analysed by LC-MS/MS after 0 h and 48 h. Details of the analytical results are given in part 4.2.2.
The recoveries in the fresh (0 h) and old media (48 h) were in the range of 96 to 107 % of the nominal values, demonstrating that concentrations of the test item were successfully maintained for the duration of the test. All effect values are given based on the nominal concentrations of the test item (Table 1).Water quality parameters of pH-value and dissolved oxygen concentration, measured at 0 and 48 h, were determined to be within the acceptable limits. The validity criteria of the test guideline were fulfilled.The EC50 after 48h was determined to be:EC50: 70.7 mg/l.

 

Evaluation: valid without restrictions, Klimisch-I , Key study

Assessment: The test item harmful to daphnia.