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Registration Dossier
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EC number: 500-066-5 | CAS number: 28961-43-5 1 - 6.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Short-term aquatic toxicity:
Reliable short-term toxicity tests for the registered substance are available for fish, algae and for daphnia.
One acute fish study is available. Fish were exposed for 96h in a static system. The LC50 was 1.95 mg/L (PARAD consortium, NOACK, 2010).
In the one available acute daphnia study, Daphnia Magna were exposed for 48h in a static system. The EC50 was 70.7 mg/L (PARAD consortium, NOACK, 2010).
In the one available algae study, the 72h-EC50 for growth rate was 2.2 mg/L (PARAD consortium, NOACK, 2010).
Long-term aquatic toxicity:
In Annex IX of Regulation (EC) No 1907/2006, it is laid down that chronic toxicity tests shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on environment.
In addition, a long-term algae EC10 of 0.323mg/L was measured. This effect concentration below 1 mg/L explains the environmental classification with Aquatic Chronic 3 H412.
There is no need to conduct further long-term testing as:
The quantitative safety assessment showed PEC/PNEC well below 1 for all identified uses - despite that a high assessment factor for the derivation of the PNECs for fresh and marine water was applied.
The substance is readily biodegradable so it will not persist in the environment
The short-term toxicity tests showed no unexpected sensitivity of a group of organisms to the substance
Toxicity to microorganisms:
A reliable study assessing the toxicity of the registered substance to microorganisms (OECD 209) is available. Based on the respiration rate, the EC20 was determined to be 292 mg/l whereas the EC50 is > 1000 mg/l (PARAD consortium, NOACK, 2010).
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