Registration Dossier
Registration Dossier
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EC number: 500-066-5 | CAS number: 28961-43-5 1 - 6.5 moles ethoxylated
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term aquatic toxicity:
Reliable short-term toxicity tests for the registered substance are available for fish, algae and for daphnia.
One acute fish study is available. Fish were exposed for 96h in a static system. The LC50 was 1.95 mg/L (PARAD consortium, NOACK, 2010).
In the one available acute daphnia study, Daphnia Magna were exposed for 48h in a static system. The EC50 was 70.7 mg/L (PARAD consortium, NOACK, 2010).
In the one available algae study, the 72h-EC50 for growth rate was 2.2 mg/L (PARAD consortium, NOACK, 2010).
Long-term aquatic toxicity:
In Annex IX of Regulation (EC) No 1907/2006, it is laid down that chronic toxicity tests shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on environment.
In addition, a long-term algae EC10 of 0.323mg/L was measured. This effect concentration below 1 mg/L explains the environmental classification with Aquatic Chronic 3 H412.
There is no need to conduct further long-term testing as:
The quantitative safety assessment showed PEC/PNEC well below 1 for all identified uses - despite that a high assessment factor for the derivation of the PNECs for fresh and marine water was applied.
The substance is readily biodegradable so it will not persist in the environment
The short-term toxicity tests showed no unexpected sensitivity of a group of organisms to the substance
Toxicity to microorganisms:
A reliable study assessing the toxicity of the registered substance to microorganisms (OECD 209) is available. Based on the respiration rate, the EC20 was determined to be 292 mg/l whereas the EC50 is > 1000 mg/l (PARAD consortium, NOACK, 2010).
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