Registration Dossier
Registration Dossier
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EC number: 272-713-7 | CAS number: 68909-79-5 An inorganic pigment that is the reaction product of high temperature calcination of principally chromium (III) oxide forming a crystalline hematite. Its composition may include any one or a combination of the modifiers Al2O3, Fe2O3, or Mn2O3.
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because a pre-natal developmental toxicity study is available
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- developmental toxicity
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Based on the explanation given in the read-across assessment framework document (attached in IUCLID section 13.2) an analogue approach for read-across of the endpoint “developmental toxicity" from the structural analogues to the target substance is considered justified.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Species:
- rat
- Key result
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Remarks:
- no effects where observed with neither of the two source substances (managnese alumina pink corundum and chromium iron oxide)
- Abnormalities:
- no effects observed
- Key result
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Remarks:
- no effects where observed with neither of the two source substances (managnese alumina pink corundum and chromium iron oxide)
- Abnormalities:
- no effects observed
- Developmental effects observed:
- no
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
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