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EC number: 272-713-7 | CAS number: 68909-79-5 An inorganic pigment that is the reaction product of high temperature calcination of principally chromium (III) oxide forming a crystalline hematite. Its composition may include any one or a combination of the modifiers Al2O3, Fe2O3, or Mn2O3.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- Minor deviations without an effect on the results: - According to the guideline, the relative humidity in the animal room should be 30 - 70 %. In this study the humidity was slightly higher (55% +/- 25 %). - According to the guideline, approx. 24 h before the test the fur should be removed by clipping or shaving. In this study it was not stated when the fur was removed. - According to the guideline, justification for choice of vehicle must be stated. In the report it was not stated, if the test substance (solid) was moistened with water or a vehicle. - According to the guideline, the age, the weight at the conclusion of the test and the source of the animals should be stated. This information was missing in the report. - According to the guideline a narrative description of the degree and nature of irritation observed must be included in the report. This was missing in this report. Only the scoring of erythema and oedema were stated.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1992-07-17
- Deviations:
- yes
- Remarks:
- , see "rational for reliability"
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hematite, chromium green black
- EC Number:
- 272-713-7
- EC Name:
- Hematite, chromium green black
- Cas Number:
- 68909-79-5
- Molecular formula:
- Cr2O3
- IUPAC Name:
- Hematite, chromium green black
- Test material form:
- solid
- Details on test material:
- - Physical state: Not stated, but it is common knowledge that this test substance is a solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Authorised supplier
- Weight at study initiation: animal #1: 2652 g; animal #2: 2501 g; animal #3: 2654 g
- Housing: Individual stainless steel cages, brand Tecniplast
- Diet: Daily dose of 150 g of special diet for experimental rabbits, provided by an authorised provider
- Drink (ad libitum): Automatic, treated and filtered at 5 µm
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature: 21 ° C (+/- 2°C)
- Relative humidity: 55 % (+/- 25 %)
- Air: Renewed 15 times per hour and prefiltered at 5 µm
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: No data: "In case of solid samples, 0.5 g are applied humidifying sufficiently with water (or appropriate fluid) to ensure a good contact with skin."
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g are applied humidifying sufficiently with water (or appropriate fluid) to ensure a good contact with skin.
- Duration of treatment / exposure:
- maximum time of exposure was 4 hours
- Observation period:
- 1 hour, 24 hours, 48 hours, 72 hours, 7 days and 14 days after removal of the bandages
- Number of animals:
- 3 male rabbits
- Details on study design:
- TEST SITE
- Area of exposure: The rabbits were shaved at the back retro-scapular area close to the vertebral column, in a 20 cm long, 13 cm wide rectangle. Once the rabbit has been shaved, the sample was applied directly on the skin, on a surface approx. 6 cm^2.
- Type of wrap if used: The test site was covered with a bandage, it was held with plaster and covered with a hypoallergenic plaster bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The studied sample was softly removed with water or appropriate solvent.
- Time after start of exposure:Once the period of exposure was over.
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- All skin effects observed were reversed by day 14.
1-hour observation in rabbits:
Animal #1:
Erythema: Score 1 (very slight (hardly perceptible)
Oededma: Score 0 (none)
Animal #2:
Erythema: Score 1 (very slight (hardly perceptible)
Oededma: Score 0 (none)
Animal #3:
Erythema: Score 1 (very slight (hardly perceptible)
Oededma: Score 0 (none)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Given that a mean value of 2 or higher was not observed in any of the tested animals, it can be concluded that the sample submitted "VERDE-D7 (B2240) ((Hematite chromium green black) does not generate skin irritation.
According to the EC Regulation No. 1272/2008 and subsequent regulations, the test item is not classified as skin irritant.
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