Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Amides, C16-C18 (even), N,N'-ethylenebis exhibited no toxicity to invertebrates within the range of water solubility 

Key value for chemical safety assessment

Additional information

Two studies investigating the acute toxicity of Amides, C16-C18 (even), N,N'-ethylenebis to Daphnia magna were available. A report from the Japanese Ministry of Environment (MOE) was chosen as key study. The test was equivalent to the one included in the OECD Guideline No. 202: Daphnia sp., Part I- Acute Immobilisation Test (1984). The results show that after 48 hours exposure to the test compound, up to the highest attainable concentration (0.0022 mg/L), no immobilization was observed on Daphnia magna. Therefore, the 48h-EC50 was greater than 0.0022 mg/L and no toxicity was observed within the range of water solubility. The test performed in the supporting study (Heyner, 2002) was carried out according to the OECD Guideline No. 202: Daphnia sp., Part I- Acute Immobilisation Test (1984), but not under GLP conditions. Immobilisation was assessed in daphnids exposed to four (nominal) test concentrations, 10, 100, 1000 and 10000 mg/L, after 24 and 48 hours. At the end of the test (48 hours) the 48h-EC50 was greater than 10000 mg/L.

 

In conclusion, Amides, C16-C18 (even), N,N'-ethylenebis exhibited no toxicity to Daphnia magna within the range of water solubility.