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EC number: 271-846-8 | CAS number: 68609-97-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 1980 to April 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed under GLP conditions with only 3 days observation.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The procedure involved the application of undiluted test material (at three dose levels) to the intact skin of sexually mature male rabbits. Ten animals, randomly selected, were used in each group. A fourth group of rabbits served as the sham control. Animals were exposed to the test material (0.5, 1.5 and 4.5 mL/kg bw) for 24 hours. They were sacrificed 72 hrs after initial application. Tissues that were collected during necropsy were evaluated histologically on a blind basis. Complete blood count was determined and evalated statistically.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- other: Multi-dose acute percutaneous toxicity in rabbits
Test material
- Test material form:
- other: liquid
- Details on test material:
- I.D. Number: J0165.01
Storage conditions: room temperature in glass bottle
Characteristics: Colorless liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- The animal maintenance was according to DHEW Standards in a USDA registered, AAALAC accredited facility.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The appropriate amount of test material was applied to a pre-cut patch (pad with Blenderm backing) and placed on the clipped back of each rabbit. dental dam was placed over the entire test site and held in place by several wrappings of Elastoplast tape. The animals were placed in Newmann harness and returned to their cages for 24 hours. After 24 hours , the harness and wrapping were removed. The test site were rinsed off under a sink with tepid water for 25-30 seconds and were blotted with paper towels. Approximately 30 minutes after the test sites were dry, teh test sites were evaluated for skin irritation.
- Duration of exposure:
- 24 hopurs
- Doses:
- Group I: Control
Group II: 4.5 mL/kg
Group III: 1.5 mL/kg
Group IV: 0.5 mL/kg - No. of animals per sex per dose:
- 10 male animals per test group
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 3 days after dosing
- Frequency of observations: Skins were graded 30 minutes aftre removal of the patches and again 3 days aftre dosing. Body weight at start and end of the study.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, skin reaction, hematology - Statistics:
- Where appropriate, the results were compared statistically using the method of analysis of variance at <= 0.05 (G.W. Snedecor and W.G. Cochran in statistical Methods, P.258, Iowa State U. Press, 1978).
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- >= 4.5 mL/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occured during the course of the study.
- Clinical signs:
- other: No test article related changes in normal behavior or physiological processes were observed during the study.
- Gross pathology:
- No test article related gross lesions were observed at necropsy.
- Other findings:
- Only slight irritation was observed at 24 hours, and moderate irritation was reported after 72 hours in all treated groups. Immediately prior to sacrifice, blood was collected from the vena cava of each animal and checked for Hgb, Hct, WBC, RBC, and differential leukocyte counts. Organ weights were determined for testes with and without epididymis, and for liver, heart, kidneys and brain. The testes, epididymis, ductus deferens, seminal vesicles, prostate and heart were further subjected to histopathological examination. There were no compoundrelated effects on body weight, organ weights, and blood morphology, and no adverse effects observed at gross necropsy or histopathological examinations
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Based on the sudy results, the dermal LD50 in rabbits is considered to be greater than 4.5 mL/kg (equivalent to 4000 mg/kg)
- Executive summary:
Sexually mature male New Zealand albino rabbits were exposed dermally to doses of alkyl (Cl2-C14) glycidyl ether, ranging from 0.5 to 4.5 ml/kg (equivalent to 4 g/kg). The test material was applied undiluted. There was no mortality. Only slight irritation was observed at 24 hours, and moderate irritation was reported after 72 hours in all treated groups. Immediately prior to sacrifice, blood was collected from the vena cava of each animal and checked for Hgb, Hct, WBC, RBC, and differential leukocyte counts. Organ weights were determined for testes with and without epididymis, and for liver, heart, kidneys and brain. The testes, epididymis, ductus deferens, seminal vesicles, prostate and heart were further subjected to histopathological examination. There were no compoundrelated effects on body weight, organ weights, and blood morphology, and no adverse effects observed at gross necropsy or histopathological examinations.
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