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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets National standards method with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report Date:
1977

Materials and methods

Principles of method if other than guideline:
Four albino rats were exposed to a saturated atmosphere (nominal concentration: 0.15 mg/l) for 7 hours at room temperature.
GLP compliance:
no
Test type:
fixed concentration procedure

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
air
Concentrations:
saturated atmosphere (nominal concentration: 0.15 mg/l)
No. of animals per sex per dose:
4

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC0
Effect level:
0.15 mg/L air
Based on:
test mat.
Exp. duration:
7 h
Remarks on result:
other: limited data
Mortality:
0%
Clinical signs:
Moderate eye and nasal irritation was observed in all animals during the exposure
Body weight:
No adverse body weight changes

Applicant's summary and conclusion

Conclusions:
The 7 hour LC 50 > 0.15mg/l (a saturated atmosphere).
Executive summary:

The exposure of 4 albino rats to the saturated atmosphere (nominal concentration (0.15 mg/l) for 7 hours at room temperature resulted in 100% survival. Moderate eye and nasal irritation was observed in all animals during the exposure.