Registration Dossier
Registration Dossier
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Oligomer of 4,4-bis(1,1,3,3-tetramethylbutyl)diphenylamine with N-(4-(2,4,4-trimethylpentan-2-yl)phenyl)naphthalen-1-amineor (according to REACH Guidance on substance identification)Reaction mass of N,N,N'-tri(4-(1,1,3,3-tetramethyl-butyl)phenyl-N'-(di(4-(1,1,3,3-tetramethylbutyl)phenyl)amino)-naphthylhydrazine, N,N,N'-tri(4-(1,1,3,3-tetramethyl-butyl)phenyl-N'-(bis-(di(4-(1,1,3,3-tetramethylbutyl)phenyl)amino))-naphthylhydrazine, N,N,N'-tri(4-(1,1,3,3-tetramethyl-butyl)phenyl-N'-(bis(N''-(4-(1,1,3,3-tetramethylbutyl)phenyl)amino)-N''-naphthyl)naphthylhydrazine, N,N,N'-tri(4-(1,1,3,3-tetramethyl-butyl)phenyl-N'-[x-(di-(4-(1,1,3,3-tetramethylbutyl)phenyl)amino-(4-(1,1,3,3-tetramethylbutyl)phenyl)-amino)naphthylamino)naphthyl-hydrazine, tetrakis 4-(1,1,3,3-tetra-Methyl-butyl)phenylhydrazine and N,N,N'-tris(4-(1,1,3,3-tetramethyl-butyl)phenyl-N'-naphthylhydrazine
EC number: 415-860-6 | CAS number: 68938-84-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: SNIF data only provide max score, however a score range was provided (0 to max score) in order to fulfill completeness
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 415-860-6
- EC Name:
- -
- Cas Number:
- 68938-84-1
- IUPAC Name:
- 1-(naphthalen-1-yl)-2,2-bis(4-octylphenyl)-1-[4-(2,4,4-trimethylpentan-2-yl)phenyl]hydrazine; 1-N-[2-({2-[bis(4-octylphenyl)amino]-4-octylphenyl}(4-octylphenyl)amino)-4-octylphenyl]-1-N-(4-octylphenyl)-4-N-[4-(2,4,4-trimethylpentan-2-yl)phenyl]naphthalene-1,4-diamine; 1-N-{2-[bis(4-octylphenyl)amino]-4-octylphenyl}-1-N-(4-octylphenyl)-4-N-[4-(2,4,4-trimethylpentan-2-yl)phenyl]naphthalene-1,4-diamine; 4-octyl-N-(4-octylphenyl)aniline; 5-[2,2-bis(4-octylphenyl)-1-[4-(2,4,4-trimethylpentan-2-yl)phenyl]hydrazin-1-yl]-1-N,1-N,3-N,3-N-tetrakis(4-octylphenyl)naphthalene-1,3-diamine; 5-[2,2-bis(4-octylphenyl)-1-[4-(2,4,4-trimethylpentan-2-yl)phenyl]hydrazin-1-yl]-N,N-bis(4-octylphenyl)naphthalen-2-amine; 5-octyl-1-N,1-N,2-N-tris(4-octylphenyl)benzene-1,2-diamine; tetrakis(4-octylphenyl)hydrazine
- Details on test material:
- Nature of substance: solid, ground with mortar and pestle
Constituent 1
Test animals / tissue source
- Species:
- other: Rabbit, New Zealand White
Test system
- Amount / concentration applied:
- 0.1 ML
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- other: 0.83
- Score:
- 0 - <= 1.5
- Max. score:
- 1.5
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Max duration: h; Max. value at end of observation period: 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 0.25
- Score:
- 0 - <= 1.5
- Max. score:
- 0.67
- Reversibility:
- fully reversible
- Remarks:
- 7 days
- Remarks on result:
- other: Max duration: 72h; Max. value at end of observation period: 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 0
- Score:
- 0 - <= 1.5
- Max. score:
- 0
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Max. duration: 0h; Max. value at end of observation period: 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 0.06
- Score:
- 0 - <= 1.5
- Max. score:
- 0.17
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Max. duration: 48h; Max. value at end of observation period: 0
- Irritant / corrosive response data:
- Reversibility of any effect observed: Changes fully reversible within 7 days
- Other effects:
- Residual test material was observed around the eyes for the 7 days observation period.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
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