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EC number: 265-159-2 | CAS number: 64742-56-9 A complex combination of hydrocarbons obtained by removal of normal paraffins from a petroleum fraction by solvent crystallization. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C15 through C30 and produces a finished oil with a viscosity of less than 100 SUS at 100°F (19cSt at 40°C).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1980-10-21 to 1980-10-28
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was classified as reliable with restriction. The study is an acceptable, well-documented study report that followed sound scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- The method did not strictly follow the guideline but is deemed appropriate as utilized in this report.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 64742-56-9
- Cas Number:
- 64742-56-9
- IUPAC Name:
- 64742-56-9
- Reference substance name:
- Solvent dewaxed light paraffinic oil, sufficiently refined, IP 346 < 3%
- IUPAC Name:
- Solvent dewaxed light paraffinic oil, sufficiently refined, IP 346 < 3%
- Test material form:
- other: Oily liquid
- Details on test material:
- - Name of test material (as cited in study report): API 78-9 Solvent dewaxed light paraffinic oil
- CAS number: 64742-56-9
- API Identification number: API 78-9
Molecular weight (if other than submission substance): 322
- Substance type: Other Lubricant Base Oil (Sufficiently Refined, IP 346 < 3%)
- Physical state: Liquid
- Analytical purity: Not reported
- Stability under test conditions: Not reported
- Storage condition of test material: Stable at room temperature
- Other:
Specific gravity 60/60: 0.8490
API gravity: 35.2
Viscosity CS: 11.5 @ 100°F
Viscosity CS: 2.81 @ 210°F
Viscosity SUS: 64.2 @ 100°F
Viscosity SUS: 35.6 @ 210°F
Viscosity Index: 97
Viscosity-gravity constant: 0.807
Pour Point: -3°F
Aniline Point: 200.5 °F
Ramsbottom Carbon:0.03%
Density 20C: 0.8453
Refractive Index ND20:1.4675
UV Absorptivity, 260 nm: 0.500
UV Absorptivity, 290 nm: 0.261
UV Absorptivity, 343 nm: 0.002
Distillation range (°F) 597-751 (5 and 95%)
Initial Boiling Point (°F): 536
Final Boiling Point (°F): 782
- Composition of test material:
ASTMD-2007, Wt. %:
Asphaltenes: 0.0
Saturates: 88.7
Aromatics 11.3
Polar compounds: 0.0
Carbon Distribution (ndm)
% Aromatic carbons: 3
% Naphthenic carbons: 30
% Paraffinic carbons: 67
Sulfur, ppm: 490
Basic Nitrogen, ppm: 20
Total Nitrogen, ppm: 237
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elkhorn Rabbitry (Watsonville, California)
- Age at study initiation: Not reported
- Weight at study initiation: 3.0 - 5.0 Kg
- Fasting period before study: Not reported
- Housing: Individual cage
- Diet (e.g. ad libitum): Purina Rabbit Chow® ad libitum
- Water (e.g. ad libitum): Fresh water ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
IN-LIFE DATES: From: 1980-10-02 To: 1980-10-28
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 7 days
- Number of animals:
- 3/sex/dose
- Details on study design:
- TEST SITE
- Area of exposure: Lateral to the midline (back) and 10 cm apart
- % coverage: Not reported
- Type of wrap if used: Plastic wrap secured with one-inch porous tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Wiped with guaze sponges
- Time after start of exposure: 24 hours
SCORING SYSTEM: Draize scoring method
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 8
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0.17
- Max. score:
- 8
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: not applicable
- Remarks on result:
- other: intact and abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: not applicable
- Remarks on result:
- other: intact and abraded skin
- Irritant / corrosive response data:
- See (Table 1) "Remarks on results including table and figures"
Any other information on results incl. tables
Table 1. Mean Dermal Irritation Scores |
||
Parameter |
Exposure time (hours) |
Exposure unit (Values*) |
Erythema |
|
|
Intact Skin |
24 |
1.00 |
Abraded Skin |
72 |
0.17 |
Subtotal = 1.17 |
||
Edema |
|
|
Intact Skin |
24 |
1.00 |
Abraded Skin |
72 |
0.17 |
Subtotal = 1.17 |
||
Total = 2.34 |
||
Primary Irritation Score = (2.34/4) = ~0.6 |
*Average value of animals recorded for dermal irritation in the study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Edema was not apparent in male or female rabbits at any observation point. Slight erythema (1) was evident in all male and female rabbits at the 24 hour observation point. Very slight erythema (1) was observed in only 1 male rabbit by the 72 hour observation point and no irritation was visible in any test animal by the end of the 7-day observation period. No differences in irritation were observed between intact and abraded skin sites.
API 78-9 when administered dermally was not considered to be irritating to the intact and abraded skin of New Zealand White rabbits - Executive summary:
In a primary dermal irritation study, 6 New Zealand White rabbits (3 male/3 female) were dermally administered 0.5 mL solvent dewaxed light paraffinic oil under occlusive wrap for 24-hours. After the exposure period, the bandages were removed and test sites were wiped with guaze sponges. The animals were observed thereafter and dermal irritation was scored using the method of Draize at 24 hours, 72 hours and on Day 7 post-exposure.
Edema was not apparent in male or female rabbits at any observation point. Very slight erythema (1) was evident in all male and female rabbits at the 24 hour observation point. Very slight erythema (1) was observed in only 1 male rabbit by the 72 hour observation point and no irritation was visible in any test animal by the end of the 7-day observation period. No differences in irritation were observed between intact and abraded skin sites.
Solvent dewaxed light paraffinic oil is not considered to be irritating to the skin of rabbits.
This study is classified as 'reliable with restriction' because although the study is well documented and scientifically acceptable, the results for the 48-hour observation period were not reported as recommended by acceptable guidelines. Adverse systemic effects such as signs of clinical toxicity and body weight were not conducted and/or reported.
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