Registration Dossier
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EC number: 203-905-0 | CAS number: 111-76-2
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
NOAEC (21 day) > 100mg/l
NOAEC (14 day) > 100mg/l
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
In a 21 day study in fish (Brachydanio rerio) that was designed to examine the potential for endocrine disrupting effects and which was based around the OECD guideline, there was no evidence of any adverse effects, including on endocrine markers, up to and including the maximum tested dose of 100mg/l. The results lead to the conclusion that 2 -butoxyethanol has no potential for endocrine disruption.
In a well reported guideline OECD204 study, Oryzias latipes were exposed to 2 -butoxyethanol in a flow through exposure system at water concentrations of up to 100mg/L for a period of 14 days. No mortality was observed. There was no effect on morphology, breathing or swimming behaviour. The only treatment related observations made was a reduction in feeding behaviour on one day in the mid dose group and for three consecutive days in the high dose group. Feeding behaviour was similar across all groups at the end of the study so this change was not assessed as adverse. The no adverse effect at the end of the study was deemed to be 100mg/L, the maximum tested dose.
These studies together are considered sufficient to meet the requirements for this end point. A study for a further 7 days in length is unlikely to result in a different outcome.
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