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EC number: 203-366-1
CAS number: 106-14-9
A 16 wk study, including two feeding
trials (90 d, respectively), were conducted to investigate the
subchronic oral toxicity of the test substance in Wistar rats (Slonaker
substrain of Wistar strain).
In the 90 d subacute toxicity feeding trial,
weanling female rats (three per group) were fed diets containing 0-20%
test substance. Prior to autopsy, blood samples were taken for
hematological study. At autopsy,organ weights were recorded and numerous
tissues were preserved for microscopic pathological examination.
The trial was repeated but the test
substance was dissolved in corn oil before being added to the diet.
In the main study, of 16 wk, a total of 90
young albino male rats were segregated into groups of six. Weekly
records of individual body weights and food intake by group were
maintained. The diet fed contained either 20% corn oil (control diet),
1% test substance and 19% corn oil or 10% test substance and 10% corn
oil. After eight wk of feeding, half of the groups of rats on diets
containing the test substance were given the corn oil diet until the end
of the experiment at 16 wk. On the fifth wk, three rats fed 1% and 10%
test substance were autopsied. At eight weeks and twelve weeks, sets of
three rats on the corn oil diet were also autopsied.
Treatment-related effects were not
observed, except for reduced growth rate in rats given 10% test
substance in their diet. A No Observed Effect Level (NOAEL) was
therefore established to 10% (ca. 5,000 mg/kg bw/day).
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