Registration Dossier

Administrative data

Endpoint:
biodegradation in soil
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Study period:
Not applicable
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Estimation according to level III fugacity model and Biowin3 of EPIWIN
Justification for data waiving:
other:
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
other: software
Title:
Level III fugacity model and Biowin3 (EPIWEB v 4.0)
Author:
U.S. Environmetal Protection Agency
Year:
2009
Bibliographic source:
US EPA. [2009]. Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.00. United States Environmental Protection Agency, Washington, DC, USA.

Materials and methods

Principles of method if other than guideline:
The biodegradation in water estimated using Biowin 3 in terms of ‘time-range’, is used for half-life derivation, by application of conversion factors. EPISUITE assumes conversion of biodegradation rate for a chemical in soil as, on average, one-half (1/2) that in water.

Test type:
other: Estimated soil half-life from Biowin3 of EPIWIN

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 12-hydroxystearic acid
- Composition of test material, percentage of components: Data can be provided by the sponsors
- Physical state: Solid
- Composition of test material, percentage of composition: Data can be provided by the sponsors
- Purity test date: April 09, 2010
- Expiration date of the lot/batch: April 09, 2011
- Storage condition of test material: In original container, at room temperature (15 – 25 °C), in the dark
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
Not applicable

Study design

Oxygen conditions:
other: Not applicable
Soil classification:
other: Not applicable
Details on soil characteristics:
Not applicable
Initial test substance concentration
Based on:
other: Not applicable
Parameter followed for biodegradation estimation:
other: Not applicable
Experimental conditions
Temp.:
Not applicable
Humidity:
Not applicable
Microbial biomass:
Not applicable
Details on experimental conditions:
Not applicable

Results and discussion

Material (mass) balance
% Recovery:
78.2
Remarks on result:
other: estimated using the Level III Fugacity Model of EPIWIN
Half-life / dissipation time of parent compound
DT50:
8.67 d
Type:
other: first-order kinetics
Remarks on result:
other: Converted by Biowin 3 (EPIWIN), assuming that (a) 6 half-lives constitutes the "complete" degradation of a substance, (b) first-order kinetics (c) biodegradation rate for a chemical in soil is, on average one-half (1/2) that in water
Transformation products:
not measured
Identity of transformation products
Reference
Reference substance name:
Unnamed
IUPAC name:
not applicable
Identity:
not applicable
Details on transformation products:
Not applicable
Evaporation of parent compound:
not measured
Volatile metabolites:
not measured
Residues:
not measured
Details on results:
See below under 'Any other information on results incl. tables'
Results with reference substance:
Not applicable

Any other information on results incl. tables

Soil Half-life estimation:

The test substance biodegradation in water (time range) and its assigned half-life by BIOWIN3 is as follows:

 

BIOWIN Output          

Converted assigned half-life in water (days)

Converted half-life in soil (days)

Converted half-life in sediment (days)

Days to Weeks                

8.67

17.3

78.03

 

 

Percent distribution:

The estimated percent distribution of the test substance in different environmental compartments using the Level III Fugacity Model are:

        

Mass

Amount 

(percent)       

Half-Life (h)

Emissions (Kg/h)

 

Air

0.363

8.16        

1000 

Water

21

208

1000

Soil

78.2

416

1000

Sediment

0.422

0.00187   

0

Persistence Time

391 h

Applicant's summary and conclusion

Conclusions:
The estimated percent distribution and BIOWIN determined half life of the test substance in soil using Fugacity level III model and BIOWIN3 (EPIWEB v 4.0) was 78.2% and 416 h (i.e.17.3 days) respectively.
Executive summary:

The percent distribution and biodegradation of 12-hydroxystearic acid in soil was determined using level III fugacity model and Biowin 3 of EPIWEB v 4.0. The input parameters for this model were SMILES and CAS number of the test substance.

Distribution data in soil was estimated using Mackay level III fugacity modeling. This model is a direct adaption of the methodology as Mackay’s EQC model, and is a well established and validated distribution model. The biodegradation in soil was estimated using Biowin 3 by application of suitable conversion factors as, on average, one-half (1/2) that in water. 

The estimated percent distribution and BIOWIN determined half life of the test substance insoil using Fugacity level III model and BIOWIN3 (EPIWEB v 4.0) was78.2% and 416 h (i.e.17.3 days)respectively.