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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Original publication in Czech; only few data could be extracted from an English abstract and from tables; However, peer reviewed data used as supporting data for HPV submission (US EPA); Scientifically acceptable.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Experimental studies of toxic effects of 1,3,5-trioxane and 1,3-dioxolane. I. Acute toxic effects
Author:
Czajkowska T, Krysiak B and Popinska E
Year:
1987
Bibliographic source:
Med Pr Vol 38 :184-190
Reference Type:
secondary source
Title:
1,3,5-TRIOXANE, CAS Number 110-88-3, USEPA HPV Challenge Program Submission
Author:
Trioxane Manufacturers Consortium Members, BASF Performance Copolymers, LLC (Formerly Ultraform Company) and Ticona
Year:
2000
Bibliographic source:
USEPA HPV Submission

Materials and methods

Principles of method if other than guideline:
The acute systemic toxicity of trioxane in rat following single administration by gavage was examined and the LD50 was determined using the Litchfield and Wilcoxon method.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3,5-trioxane
EC Number:
203-812-5
EC Name:
1,3,5-trioxane
Cas Number:
110-88-3
Molecular formula:
C3H6O3
IUPAC Name:
1,3,5-trioxane
Details on test material:
Trioxane
Purity assumed to be ca. 98% (impurities reported: 2% H2O, 0.5% CH2O, 0.1% HCOOH)



Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
Designation: Wistar rats
Source: no data
Age at test initiation: no data
Body weight range at test initiation: 250 - 300 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
Not recognizable
No. of animals per sex per dose:
no data
Control animals:
not specified
Statistics:
The determination of the LD50 was based on the Litchfield and Wilcoxon method.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
8 500 mg/kg bw
95% CL:
7 320 - 9 860

Applicant's summary and conclusion