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EC number: 931-203-0 | CAS number: -
In a subchronic toxicity study according to OECD guideline 407 (1995) and EU method B7 (1996) the test substance partially unsaturated TEA-Esterquat, was administered to 5 CD rats/sex/dose by gavage at dose levels of 0,100, 300 and 1000 mg/kg bw/day for 28 days. A satellite group of 5 males and 5 female for the control and high dose group was included to assess the reversibility of any effects after a 2-week recovery period.
No mortality and no influence on behavior, external appearance, body weight, food and drinking water consumption, the eyes or optic region, the haematological and clinical-biochemical parameter and the relative or absolute organ weights at any of the tested dose levels was noted. No test item-related changes were revealed during neuropharmacological functional observations in any of the dosed groups.
Macroscopic post mortem examination and histopathology including the reproductive organs (epididymis, ovary, prostate, testicle and uterus) revealed no test item related changes in the partially unsaturated TEA-Esterquat treated animals.
There is no evidence for a specific target organ toxicity in this study.
Under test conditions, the NOAEL was above 1000 mg/kg bw /day in this 4- week subchronic toxicity study.
The analytical verification of dosing solutions demonstrated agreement of actual initial concentrations with nominal test concentrations.
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