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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
other: case report
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract

Data source

Reference
Reference Type:
publication
Title:
Contact Dermatitis from Azodicarbonamide in Earplugs.
Author:
Yates VM ; Dixon JE
Year:
1988
Bibliographic source:
Contact Dermatitis, Vol. 19, No. 2, pages 155-156, 1988

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
C,C'-azodi(formamide)
EC Number:
204-650-8
EC Name:
C,C'-azodi(formamide)
Cas Number:
123-77-3
Molecular formula:
C2H4N4O2
IUPAC Name:
(E)-(carbamoylimino)urea; (Z)-(carbamoylimino)urea

Method

Type of population:
occupational
Ethical approval:
not specified
Subjects:
A 58-year-old textile worker presented with recurrent bilateral otitis externa.
During the course of his work, he wore yellow foam earplugs (EAR plugs; Cabot Safety Ltd.).
Patch tests to the ICDRG standard series were negative but a positive (++) reaction to his earplug was noted at 48 and 96 h.
3 months later, he was patch tested to the components of the earplugs. These included the blowing agent, azodicarbonamide.

Results and discussion

Results of examinations:
Patch tests to azodicarbonamide 1% pet. and 5% pet. were repeated in 10 controls with negative results.
The patient's otitis externa cleared on discarding his earplugs.

Applicant's summary and conclusion