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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
biochemical or cellular interactions
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Crocidolite-induced lipid peroxidation in rat lung microsomes. I. Role of different ions.
Author:
Gulumian M, Kilroe-Smith TA
Year:
1987
Bibliographic source:
PMID 3034563 Environmental Research 43(1):267-73.

Materials and methods

Endpoint addressed:
basic toxicokinetics

Test material

Constituent 1
Reference substance name:
Iron trichloride
EC Number:
231-729-4
EC Name:
Iron trichloride
Cas Number:
7705-08-0
IUPAC Name:
iron(3+) trichloride

Results and discussion

Details on results:
Lipid peroxidation is increased by ferrous or ferric ions in rat lung microsomes both from rats pretreated with 3-methylcholanthrene and from untreated controls. This increase was dependent on the concentration of these ions in the reaction mixture. A reduced pH enhanced the rate of lipid peroxidation in line with increased solubility of iron salts at these pH values.

Applicant's summary and conclusion

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