Registration Dossier
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EC number: 700-206-7 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 48 h LC0 of the test material to Daphnia magna was considered to be 50 mg/L based on read)-across to data obtained for a comparable substance
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Synthetic inositol phosphates are composed of a mix of inositol phosphates (25.0 – 38.4%) and orthophosphoric acid (23.8 – 26%). The toxicity
of this test material to Daphnia can therefore be determined based on data on these two components :
- Inositol phosphates: A study conducted on the test material (‘Inositol phosphates from rice bran’) containing a comparable amount of inositol phosphates (26.8 - 29.1%) but less orthophosphoric acid (0.4 – 1%) yielded an estimated 48 h LC0 for Daphnia magna = 50 mg/L (calculated from total organic carbon analysis results, taking into account test material settling during the study related to hardness of the daphnia medium). Read-across between the two substances is considered possible as their inositol phosphate content and physico-chemical properties (e.g. water solubility, log Kow, melting/freezing point, boiling point, relative density and surface tension) were shown to be in comparable ranges.
- Orthophosphoric acid: According to the IUCLID 2000 dataset (http://ecb.jrc.ec.europa.eu/IUCLID-DataSheets/7664382.pdf), toxicity to Daphnia of orthophosphoric acid is related to pH, not to the substance itself. Because the presence of orthophosphoric acid in ‘Synthetic inositol phosphates’ does not significantly alter the pH compared to ‘Inositol phosphates from rice bran’ (both substances have a pH <1 in undiluted form), no difference in toxicity specifically due to orthophosphoric acid is expected. Orthophosphoric acid has been shown to present low toxicity to fish, with a 96 h LC50 for mosquito fish = 138 mg/L (http://www.hillbrothers.com/msds/pdf/n/phosphoric-acid-fg.pdf).
In conclusion, the toxicity to Daphnia of ‘Synthetic inositol phosphate’ is expected to be comparable to that of ‘Inositol phosphates from rice bran’, with a 48 h LC0 = 50 mg/L.
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