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EC number: 229-176-9 | CAS number: 6422-86-2
In a subacute dermal toxicity study, 5 guinea pigs were exposed to 0.5 mL undiluted di (2-ethylhexyl) terephthalate (equating to 813 to 1144 mg/kg bw/day) 9 times over 11 days. Under the conditions of this study, no deaths occurred and no signs of skin absorption or systemic toxicity were evident during the study. At the application sites, signs of irritation were limited to moderate to severe erythema and slight edema. During the course of two weeks the erythema did not diminish in severity but the edema disappeared. A body weight gain was noted in all animals over the 2-week observation period. Based on the results of this study, di (2-ethylhexyl) terephthalate is not acutely toxic following repeated dermal application but may cause moderate irritation.
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