Registration Dossier
Registration Dossier
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EC number: 200-573-9 | CAS number: 64-02-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Summaries of toxicological data
- Author:
- Yang, S.S. et al
- Year:
- 1 964
- Bibliographic source:
- Fd. Cosmet. Toxicol. 2, 763-767 (1964)
Materials and methods
- Objective of study:
- excretion
- Principles of method if other than guideline:
- Single doses of Na2EDTA were administered and the amount excreted in urine determined.
- GLP compliance:
- no
Test material
- Reference substance name:
- Disodium dihydrogen ethylenediaminetetraacetate
- EC Number:
- 205-358-3
- EC Name:
- Disodium dihydrogen ethylenediaminetetraacetate
- Cas Number:
- 139-33-3
- Molecular formula:
- C10H14N2Na2O8
- IUPAC Name:
- disodium dihydrogen 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate
- Test material form:
- solid
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on exposure:
- no data
- Duration and frequency of treatment / exposure:
- no data
Doses / concentrationsopen allclose all
- Dose / conc.:
- 47.5 other: mg/animal
- Remarks:
- corresponding to 237.5 mg/kg bw; assuming a body weight of 200 g
- Dose / conc.:
- 95 other: mg/animal
- Remarks:
- corresponding to 475.0 mg/kg bw; assuming a body weight of 200 g
- Dose / conc.:
- 142.5 other: mg/animal
- Remarks:
- corresponding to 712.5 mg/kg bw; assuming a body weight of 200 g
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Details on dosing and sampling:
- no data
- Statistics:
- no data
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- no data
- Details on distribution in tissues:
- no data
- Details on excretion:
- The amount of EDTA excreted in urine was directly proportional to the amount ingested. The peak urinary excretion was after 4 h. The authors concluded that due to the linear relationship EDTA is most likely absorbed by diffusion.
Metabolite characterisation studies
- Details on metabolites:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
