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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Toxicological information

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Description of key information

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No studies on the toxicokinetics of Na4EDTA are available. However, several studies have been performed using CaNa2EDTA or Na2EDTA. According to the dissociation equilibrium administration of different sodium salts will result in the formation of various anionic species of EDTA in dependence on the intestinal pH value. In whatever salt EDTA is administered it is likely to chelate metal ions in vivo. Therefore the studies using CaNa2EDTA have been used as read-across. (For read-across justification also refer to section 13). It can be assumed that the systemic absorption from the intestinal tract is low. The obtained data can be used to predict that dermal absorption should be even lower. Additionally absorbed EDTA does not undergo any biotransformation and is excreted unchanged.

In toxicokinetik studies on humans as well as rats the CaNa2 and Na salts of EDTA are poorly absorbed from the gastrointestinal tract (2 -18% in rats; less than 5% in humans) CaNa2EDTA does not penetrate the skin, only 0.001% were absorbed within 24 h of administration. Intravenously applied EDTA is rapidly excreted in urine (humans 50% within the first hour 98% within 24 h; rats: 95%- 98% within 6 h). These data were also confirmed by the independent evaluation of the MAK Commission for the Investigation of Health Hazards of Chemical Compounds in the work area (MAK, 46. Lieferung, 2009).