Registration Dossier
Registration Dossier
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EC number: 208-863-7 | CAS number: 544-17-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Unsuitable test system. Route of exposure not to be considered for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Die akute und chronische Toxizität der Ameisensäure und ihrer Formiate.
- Author:
- Malorny G
- Year:
- 1 969
- Bibliographic source:
- Zeitschrift Ernährungswissenschaft 9, 332-339.
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Calcium diformate
- EC Number:
- 208-863-7
- EC Name:
- Calcium diformate
- Cas Number:
- 544-17-2
- Molecular formula:
- CH2O2.1/2Ca
- IUPAC Name:
- calcium diformate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- intravenous
- No. of animals per sex per dose:
- 55
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 154 mg/kg bw
Any other information on results incl. tables
RS-Freetext:
LD50 of formic acid and its salts in the mouse following
i.v. injection:
===========================================================
Substance LD50 range LD50 No. of
(formate #) animals
(mg/kg bw) (mg/kg bw) n
-----------------------------------------------------------
Formic acid 145 138-151 142 50
Na-formate 807 800-813 534 50
K-formate 95 93-97 51 55
NH4-formate 410 408-412 293 50
Ca-formate 154 150-158 107 55
===========================================================
# = calculated proportion of formate of the LD50 dose.
Applicant's summary and conclusion
- Conclusions:
- The LD50 of calcium formate was 154 mg/kg bw in mice following i.v. injection.
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