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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Not available
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Justification for data waiving:
other:
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1968

Materials and methods

Objective of study:
absorption
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The absorption of coconut oil was determined in a 47 wk repeated dose study in rats. At intervals during the study, feces were collected daily, pooled in weekly samples, and analyzed for fat content. The net fat absorption was calculated from dietary intakes and fecal excretion.

Test material

Constituent 1
Chemical structure
Reference substance name:
Glycerides, C8-18 and C18-unsatd.
EC Number:
266-946-3
EC Name:
Glycerides, C8-18 and C18-unsatd.
Cas Number:
67701-28-4
Molecular formula:
Triglycerides containing a glycerol backbone esterified to fatty acids with a carbon chain length of C8-18 as well as unsaturated C18 fatty acids
IUPAC Name:
Tri(C8-18 and C18-unsatd. fatty acyl)glycerol
Details on test material:
- Name of test material (as cited in study report): Coconut oil (CAS N° 8001-31-8, EC N° 232-282-8); under the SDA nomenclature, the name of this substance is ‘Glycerides, C8-18 and C18-unsatd.’
Radiolabelling:
no

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Housing: Individual screen-bottom cages
- Diet: Normal diet; ad libitum
- Water: Ad libitum


ENVIRONMENTAL CONDITIONS
Air-conditioned animal rooms

Administration / exposure

Route of administration:
oral: feed
Vehicle:
unchanged (no vehicle)
Details on exposure:
DIET PREPARATION
- Mixing appropriate amounts with (type of food): 18.5% coconut oil was mixed with diet containing additional 2.5% safflower oil as fat source to insure adequacy of the essential fatty acids. No other fat source was used in diet.
Duration and frequency of treatment / exposure:
47 wks; ad libitum in diet
Doses / concentrations
Remarks:
Doses / Concentrations:
18.5%
No. of animals per sex per dose / concentration:
15 animals/sex/group
Control animals:
no
Positive control reference chemical:
None
Details on study design:
No data
Details on dosing and sampling:
PHARMACOKINETIC STUDY (Absorption)
- Tissues and body fluids sampled: Feces
- Details: At intervals during the study, feces were collected daily, pooled in weekly samples, and analyzed for fat content. The net fat absorption was calculated from dietary intakes and fecal excretion.


Statistics:
None

Results and discussion

Preliminary studies:
None

Toxicokinetic / pharmacokinetic studies

Details on absorption:
The net fat absorption, calculated from dietary intakes and fecal excretion, was 96%. The absorption of coconut oil can be considered to be similar to this value as 2.5% safflower oil was the only other fat source in diet.
Details on distribution in tissues:
Not performed
Details on excretion:
Not performed

Metabolite characterisation studies

Metabolites identified:
not measured
Details on metabolites:
Not applicable

Any other information on results incl. tables

None

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): other: High absorption
Under the conditions of the test, coconut oil was highly absorbed after dietary administration in rats.
Executive summary:

The absorption of coconut oil was determined in a 47 wk repeated dose study in rats.

Coconut oil was included at 18.5% level in diets of 15 wistar rats/sex/group for 47 wks. Additional 2.5% safflower oil was included to insure adequacy of the essential fatty acids. At intervals during the study, feces were collected daily, pooled in weekly samples, and analyzed for fat content. The net fat absorption was calculated from dietary intakes and fecal excretion.

The net fat absorption was 96%. The absorption of coconut oil can be considered to be similar to this value as 2.5% safflower oil was the only other fat source in diet.

Hence, under the conditions of the test, coconut oil was highly absorbed after dietary administration in rats.