Registration Dossier

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Title:
Unnamed
Year:
1978
Report Date:
1978

Materials and methods

GLP compliance:
no
Remarks:
Pre GLP

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit
Strain:
Himalayan

Test system

Vehicle:
unchanged (no vehicle)
Controls:
yes, concurrent no treatment
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
Six animals

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
animal: 6/6
Time point:
other: mean 24, 48 and 72 hours
Score:
< 1
Reversibility:
fully reversible
Remarks on result:
other: rinsed and unrinsed eyes
Irritation parameter:
iris score
Basis:
animal: 6/6
Time point:
other: mean 24, 48 and 72 hours
Score:
< 1
Reversibility:
fully reversible
Remarks on result:
other: rinsed and unrinsed eyes
Irritation parameter:
conjunctivae score
Basis:
animal: 6/6
Time point:
other: mean 24, 48 and 72 hours
Score:
< 2
Reversibility:
fully reversible
Remarks on result:
other: rinsed and unrinsed eyes
Irritation parameter:
chemosis score
Basis:
animal: 6/6
Time point:
other: mean 24, 48 and 72 hours
Score:
< 2
Reversibility:
fully reversible
Remarks on result:
other: rinsed and unrinsed eyes

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information according to the CLP Regulation Criteria used for interpretation of results: EU