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Bioaccumulation: aquatic section:

Using BCFBAF Program (v3.00) model of EPI suite, the estimated bio concentration factor (BCF) for test chemical is 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore, it is concluded that test chemical is non-bio accumulative in food chain.

 

Additional information

Bioaccumulation: aquatic section:

Summarized result for the bioaccumulation of test chemical were mentioned as below:

Using BCFBAF Program (v3.00) model of EPI suite, the estimated bio concentration factor (BCF) for test chemical is 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore, it is concluded that test chemical is non-bio accumulative in food chain.

 

Above data further supported by the second data from authoritative database and secondary source. Bioaccumulation study was conducted on test organism Cyprinus carpio for evaluating the bioconcentration factor (BCF value) of test chemical. The study was performed in accordance with the OECD TG 305 C "Bioaccumulation: Test for the Degree of Bioconcentration in Fish" and other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively at 25±2°C and dissolved oxygen content of 6 -8 mg/l for 6 weeks. Cyprinus carpio (weight ca. 30 gm, length ca. 10 cm) supplied by Sugishama fish farm was used as a test organism for the study. Lipid content of the test organism at the start of exposure was 5.2%. Test organisms were fed with pelleted food about 1 % of body weight twice/day. Fishes were reared in an acclimatization tank (flow through system) for 28 days. Details on analytical methods involve the recovery ratio: Test water: 1st concentration area: 94.6%, 2nd concentration area: 91.3%, Fish: 85.9%, - Limit of quantitation: Fish : 0.093 ppm. Test chemical nominal conc. used for the study was 0.2 mg/land 0.02 mg/l. Dimethyl sulfoxide was used as a vehicle. Range finding study involves the TLm (48 hr) ≥ 50 ppm (w/v) on Rice fish (Oryzias latipes). Glass tank was used as a test vessel. Test vessel contains 15 -20 fish per level in glass tank. Total hardness, COD, chloride, and other parameters were measured every 6 months. In addition to this, water temperature, pH and dissolved oxygen were also measured continuously. The bioconcentration factor (BCF value) of test chemical on Cyprinus carpio was determined to be in the range of 1.4– 4.7 L/Kg at a conc. of 0.2 mg/l and 6.4 – 28 L/Kg at a conc. of 0.02 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.

 

 

Similar study from authoritative database and secondary source study conducted. Bioaccumulation study was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of test chemical. The study was performed according to ‘’OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)’’ and other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively. Cyprinus carpio was used as a test organism for the study. Test chemical nominal conc. used for the study was 2 mg/l and 0.2 mg/l, respectively. Analytical method involve the recovery ratio:Test water : 1st concentration area : 98.4 %, 2nd concentration area : 95.4 %, Fish : 62.2 %, - Limit of detection : Test water : 1st concentration area : 0.15 ppm, 2nd concentration area : 0.016 ppm, Fish : 2.1 ppm. Range finding study involve the TLm(48h) ≥ 1000 ppm (w/v) on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of test chemical on Cyprinus carpio was determined to be ≤ 1.1 L/Kg at a conc. of 2 mg/l and ≤ 11 L/Kg at a conc. of 0.2 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.

 

Thus based on the above predicted and experimental data on test chemical and read across chemicals, the chemical consider to be non-bio accumulative.