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EC number: 285-561-1
CAS number: 85117-09-5
Mixtures of chemical substances produced by burning (below 1200°C) natural variants of limestone or chalk containing from 10 to 20%, or more, of clayey or siliceous materials which are predominantly SiO2, Al2O3 and iron oxide. Consist primarily of 2CaOsb.2, Ca(OH)2, CaO and 2CaOsb.2O3. 3CaO.2SiO2, 4CaOsb.2O3. Fe2O3, 2CaOsb.2O3sb.2, CaCO3 and SiO2 may also be included.
Lime (chemical), hydraulic: No studies are available. However,
sensitisation by or intolerance to an abundantly available essential
element such as calcium would be grossly implausible and can therefore
safely be excluded for lime (chemical) hydraulic.
Calcium carbonate: Not sensitising in a murine LLNA (Bradshaw, 2010).
There is no evidence of any sensitization potential for calcium
compounds like lime (chemical) hydraulic. Calcium is abundantly
available in the environment, in food and extensively distributed
throughout the human body. Sensitisation by or intolerance to an
abundantly available essential element such as calcium would be grossly
implausible and can therefore safely be excluded.
This conclusion is supported by the results of a study performed
according to OECD TG 429 under GLP in which calcium carbonate (nano) was
applied topically to the dorsal surface of the ears of mice (CBA/Ca)
[Bradshaw 2010]. Three groups, each of four animals, were treated with
50 µL (25 µL per ear) of calcium carbonate as a suspension in dimethyl
formamide at concentrations of 5 %, 10 % or 25 %w/w. A further group of
four animals was treated with dimethyl formamide alone. The Stimulation
Index expressed as the mean radioactive incorporation for each treatment
group divided by the mean radioactive incorporation of the vehicle
control group was 1.74, 1.13 and 1.19 at concentrations of 5, 10 and 25
%w/w, respectively. Calcium carbonate was considered to be a non
sensitiser under the conditions of the test. None of the other
constituents or impurities are known to have sensitising properties.
In conclusion, all grades of lime (chemical) hydraulic are considered to
No information of any sensitising potential of calcium released from
hydraulic lime (chemical) is available. Hydraulic lime (chemical) does
not need to be classified for sensitisation. This is supported by data
available for calcium carbonate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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