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EC number: 285-561-1 | CAS number: 85117-09-5 Mixtures of chemical substances produced by burning (below 1200°C) natural variants of limestone or chalk containing from 10 to 20%, or more, of clayey or siliceous materials which are predominantly SiO2, Al2O3 and iron oxide. Consist primarily of 2CaOsb.2, Ca(OH)2, CaO and 2CaOsb.2O3. 3CaO.2SiO2, 4CaOsb.2O3. Fe2O3, 2CaOsb.2O3sb.2, CaCO3 and SiO2 may also be included.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- yes
- Remarks:
- Purity and stability of test item missing. Weights of the animals during the observation period missing.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Purity and stability of test item missing. Weights of the animals during the observation period missing.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 7719-01-9
- Cas Number:
- 7719-01-9
- IUPAC Name:
- 7719-01-9
- Reference substance name:
- Calcium dihydroxide
- EC Number:
- 215-137-3
- EC Name:
- Calcium dihydroxide
- Cas Number:
- 1305-62-0
- Molecular formula:
- CaH2O2
- IUPAC Name:
- calcium dihydroxide
- Details on test material:
- - Name of test material (as cited in study report): "Weisskalkteig" (from the Federal German Lime Industry Association in Cologne), which is generally known as a paste-like mixture of Calcium dihydroxide with water (white lime paste).
No further information on the test substance was stated.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Germany, External branch
- Weight at study initiation: 2.4 to 2.9 kg
- Housing: Individual cages
- Diet (ad libitum): Commercially available complete feed
- Water (ad libitum)
- Acclimation period: one week
ENVIRONMENTAL CONDITIONS
- Temperature: 21 +/- 2 °C
No further information on the test animals was given.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- The test item "Weisskalkteig" is most appropriately translated as "white lime paste". As such it is an aqeous paste-like preparation and does not require further moistening in order to ensure good skin contact.
- Details on dermal exposure:
- TEST SITE
- Area of exposure: On the day before the test sample was applied to the rabbits, the fur on their skin was sheared over an area of some 8 cm wide and 15 cm long. The test sample was applied evenly with a plastic spatula on an area of 100 cm^2 of shorn skin.
- Type of wrap if used: The treated skin area was covered with a gauze. The gauze was affixed using a "Peha-haft" dressing, so that the animal could not strip off the gauze.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The treated skin area was rinsed with water.
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): A quantity of 2.5 g/kg of body weight
No further infomration on dermal exposure was stated. - Duration of exposure:
- 24 hours
- Doses:
- 2500 mg/kg
- No. of animals per sex per dose:
- 5 males / 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days (including treatment day)
- Frequency of observations and weighing: The animals were clinically examined on a daily basis.
- Necropsy of survivors performed: Yes
On the last day of the observation phase, the rabbits were put down byintravenous injection of Pentobarbital (Nembutal R), and then immediately dissected in the Institute of Pathology, of the Hannover College of Veterinary Medicine.
- Other examinations performed: During the daily clinical observations, the general conditions were observed plus changes that occurred in the area of the fur and the treated skin, the eyes and the mucous membranes were registered and recorded.
No further information on the study design was stated. - Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Mortality:
- There were no indications of toxic effects from the test sample after dermal application.
- Clinical signs:
- other: Overall, redness, followed by scabbing, did occur in the area of the treated skin after the dressing was removed and the skin was cleaned. Slight redness after removal of the dressing was observed in one female rabbit. Moderate redness plus scabbing was o
- Gross pathology:
- Dissection of the rabbits yielded no particular results.
- Other findings:
- - Histopathology: The pathological-histological examination of the liver, kidneys, lung and skin yielded no particular results.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The available data showed that the tested White lime paste caused no acute toxic effect after dermal application. However, thest did show skin irritating effects from the test sample.
According to the EC Regulation No. 1272/2008 and subsequent regulations, the test item is not classified.
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