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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1961
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Reduction of Tetramine Toxicity by Sedatives and Anticonvulsants
Author:
Voss E., Haskell A. and Gartenberg L.
Year:
1961
Bibliographic source:
Journal of Pharmaceutical Sciences, Vol. 50, No. 10, 858-860.

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no
Remarks:
Published at 1961

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium bromide
EC Number:
231-599-9
EC Name:
Sodium bromide
Cas Number:
7647-15-6
Molecular formula:
NaBr
IUPAC Name:
Active bromine generated from sodium bromide and sodium hypochlorite
Details on test material:
Sodium Bromide. No further details

Test animals

Species:
mouse
Strain:
Swiss
Sex:
male

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
water
Doses:
no further details
No. of animals per sex per dose:
48
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
5 020 mg/kg bw

Any other information on results incl. tables

Test result is equivalent to: 3900 mg(Br-)/kg bw for the bromide ion

Applicant's summary and conclusion

Conclusions:
The test substance was administered subcutaneously in a single dose to 6 groups of Swiss mice (8 males per group) at various concentrations. Animals were observed for mortality following test substance administration. An LD50 was determined from the observation data.
LD50 value: 5.02 g/kg bw
(equivalent to: 3.896 g (Br-)/kg bw)