Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1961
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Reduction of Tetramine Toxicity by Sedatives and Anticonvulsants
Author:
Voss E., Haskell A. and Gartenberg L.
Year:
1961
Bibliographic source:
Journal of Pharmaceutical Sciences, Vol. 50, No. 10, 858-860.

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no
Remarks:
Published at 1961

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium bromide
EC Number:
231-599-9
EC Name:
Sodium bromide
Cas Number:
7647-15-6
Molecular formula:
NaBr
IUPAC Name:
Active bromine generated from sodium bromide and sodium hypochlorite
Details on test material:
Sodium Bromide. No further details

Test animals

Species:
mouse
Strain:
Swiss
Sex:
male

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
water
Doses:
no further details
No. of animals per sex per dose:
48
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
5 020 mg/kg bw

Any other information on results incl. tables

Test result is equivalent to: 3900 mg(Br-)/kg bw for the bromide ion

Applicant's summary and conclusion

Conclusions:
The test substance was administered subcutaneously in a single dose to 6 groups of Swiss mice (8 males per group) at various concentrations. Animals were observed for mortality following test substance administration. An LD50 was determined from the observation data.
LD50 value: 5.02 g/kg bw
(equivalent to: 3.896 g (Br-)/kg bw)