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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
Toxicology of the Eye
Author:
Grant W.M.
Year:
1974
Bibliographic source:
2nd ed. Springfield, Illinois: Charles C. Thomas, p. 199, 200.

Materials and methods

Type of study / information:
Type of experience: other: prognosis following poisoning

Test material

Constituent 1
Reference substance name:
medication
IUPAC Name:
medication
Details on test material:
Potassium and sodium bromides employed as sedatives and antiepileptic drugs.

Results and discussion

Results:
Overdosage with bromides causes slurring of speech, unsteadiness, depression or stupor, and psychosis. Delirium, transitory schizophrenia and hallucinations are characteristic. The literature reveals no uniform effect of overdosage on the eyes, but very commonly the pupils are large and have subnormal reaction to light or accommodation. The pupils return to normal when the patient recovers.

Applicant's summary and conclusion

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