Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

Substance specific information for the UVCB substance "Slags, precious metal refining" is not available for the endpoint “toxicokinetics”. However, there is no specific requirement to generate toxicokinetic data under Regulation (EC) 1907/2006 (REACH). Annex I, Section 1.0.2 of REACH regulation states that “The human health hazard assessment shall consider the toxicokinetic profile (i.e. absorption, metabolism, distribution and elimination) of the substance.” and REACH regulation announces in Annex VIII, Section 8.8.1 that one should perform “assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information”.

Nevertheless, for "Slags, precious metal refining", the human health (HH) hazard assessment is driven by the hazard assessment of the individual UVCB constituents which are (i) classified for HH and (ii) with a content ≥0.1 %. For most of the relevant constituents, toxicokinetic data are fully assessed and included in each individual REACH registration file but have not been included in the registration file of "Slags, precious metal refining" (see strategy of registration for UVCB substances – Precious Metals Refinables). Relevant hazard and risk assessment information for Slags, precious metal refining can be found in IUCLID Section 7 “Toxicological information_Slags, precious metal refining”.