Registration Dossier
Registration Dossier
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EC number: 939-235-7 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedures in accordance with accepted standard methods, sufficiently documented, acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- Study performed according to internal company standards (BASF-test) before actual guideline was adopted.
- GLP compliance:
- no
Test material
- Reference substance name:
- Methanol
- EC Number:
- 200-659-6
- EC Name:
- Methanol
- Cas Number:
- 67-56-1
- Molecular formula:
- CH4O
- IUPAC Name:
- methanol
- Details on test material:
- - Name of test material (as cited in study report): methanol, not further specified
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): unspecified amount
- Concentration (if solution): 100 % (undiluted) - Duration of treatment / exposure:
- 1, 5, 15 min and 20 hours (ear: only 20 hours)
- Observation period:
- 24, 48, 72 hours, 6 days and 8 days after beginning of application (exception: application time 20 hours: no observations after 24 hours)
- Number of animals:
- 2 (1, 5 and 15 min); 2 (20 hours)
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm area of skin on the back and the ear
- % coverage: not specified (application site 2.5 x 2.5 cm)
- Type of wrap if used: cotton pad soaked with the undiluted test substance, covered by an impervious bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with water, sometimes containing a mild detergent
- Time after start of exposure: 1, 5, 15 min, 20 hours (after the application)
SCORING SYSTEM: BASF scoring system, convertible to Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effect
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effect
- Irritant / corrosive response data:
- After 1, 5, 15 min of exposure, no signs of irritation (erythemy, edema) were apparent after 24, 48 and 72 hours and after 6 and 8 days. After 20 hours of exposure no signs of irritation (erythema, edema) were apparent after 48 and 72 hours and after 6 and 8 days
- Other effects:
- No mortality occurred. There were no clinical signs of systemic toxicity from the dermal exposure.
Any other information on results incl. tables
No individual animal scores given in the report
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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