Registration Dossier
Registration Dossier
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EC number: 939-235-7 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is not following any official guideline, but scientifcally valid and useful to confirm a step of the metabolic pattern of fatty acid methyl esters
Data source
Reference
- Reference Type:
- publication
- Title:
- Hydrolysis of fully esterified alcohols containing from one to eight hydroxyl groups by the lipolytic enzymes of rat pancreatic juice
- Author:
- Mattson F.H.
- Year:
- 1 972
- Bibliographic source:
- Journal of Lipid Research Volume 13, 1972
Materials and methods
- Objective of study:
- metabolism
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl oleate
- EC Number:
- 203-992-5
- EC Name:
- Methyl oleate
- Cas Number:
- 112-62-9
- Molecular formula:
- C19H36O2
- IUPAC Name:
- Methyl (Z)-octadec-9-enoate
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
- Executive summary:
The enzymatic hydrolysis in vitro of the esters of methanol, ethylene glycol, glycerol, erythritol, pentaerythritol, adonitol, sorbitol, and sucrose in which the alcohol groups were esterified with oleic acid was studied. Various preparations of rat pancreatic juice, including pure lipase, were used as the sources of enzymes. Lipase (EC 3.1.1.3) did not hydrolyze compounds that contained more than three ester groups. Compounds containing four and five ester groups were hydrolyzed by certain preparations of pancreatic juice; this activity is attributed to the enzyme, nonspecific lipase. This enzyme also hydrolyzed esters of primary alcohols. The compounds containing six (sorbitol) and eight (sucrose) ester groups were not hydrolyzed
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