Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-235-7 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
Several data on acute and chronic toxicity of methanol to fish, invertebrates, and algae are available:
Acute Toxicity
LC50 (96h) = 28100 mg/L Pimephales promelas
LC50 (96h) = 20100 mg/L Oncorhynchus mykiss (=Salmo gairdneri)
LC50 (96h) = 15400 mg/L Lepomis macrochirus
EC50 (48h) > 10000 mg/L Daphnia magna
EC50 (96h) ca. 22000 mg/L Selenastrum capricornutum (new name: Pseudokirchnerella subcapitata)
Chronic Toxicity
NOEC (200h) = 7900 - 15800 mg/L Oryzias latipes
Microorganisms
EC 50: 19800 mg/L activated sludge
IC50: >1000 mg/L avtivated sludge
IC50: 880 mg/L Nitrosamonas
toxic limit concentration: 530 - 6600 mg/L Pseudomonas, Microcystis aeruginosa.
The results indicate a very low acute toxicity for aquatic organisms, well above 10000 mg/L. Also for microorganisms data indicate a low toxicity. The PNEC for aquatic organisms was derived from the LC50 (96h) = 15400 mg/L Lepomis macrochirus using an assessment factor of 100. The choice of this assessment factor is based on the very low acute toxicity of methanol in all throphic levels and its unspecific mode of action (non-polar narcosis). Although the available information on long-term toxicity in fish (Gonzales-Doncel et al., 2008) is not used to derive the PNEC, the reported No Observed Effect Concentration of
7900 - 15800 mg/L in Oryzias latipes confirms the low toxicity of methanol also after chronic exposure.
This is also supported by available tests on chronic toxicity for Daphnids conducted with the structurally related substances propan-2 -ol and butan 1 -ol (NOECs respectively of > 100 mg/L and 18 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
