Registration Dossier
Registration Dossier
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EC number: 271-735-4 | CAS number: 68606-26-8
Endpoint summary
Administrative data
Description of key information
The substances in the category are gases and will predominantly partition to the atmosphere, which will limit the aquatic toxicity. Due to the difficulty associated with conducting aquatic toxicity tests, experimental data were available for only one member of this category: Benzene (CAS 71-43-2). The lowest acute and chronic toxicity values for benzene are an 96-hour LC50 for Oncorhynchus mykiss of 5.3 mg/L and a 32-day NOEC for Pimephales promelas of 0.8 mg/L.
In the absence of measured data, data for the other representative constituents of the category were predicted using the QSAR model ECOSAR (Program v1.00 in EPI Suite v4.00). The short term toxicity of the constituents was predicted to range from 6.97 mg/L to 623 mg/L for the different aquatic taxonomic groups.The long term toxicity of the constituents was predicted to range from 0.834 mg/L to 51.5 mg/L for the different aquatic taxonomic groups.
Additional information
Experimental data
The 96-hour LC50 for benzene for Oncorhynchus mykiss was 5.3 mg/L.
The 32-day NOEC for benzene for Pimephales promelas was 0.8 mg/L.
The 48-hour EC50 for benzene for Daphnia magna was 10 mg/L.
The 7-day NOEC for benzene for Ceriodaphnia dubia was 3 mg/L.
The 72-hour EC50 and EC10 for benzene for Pseudokirchneriella subcapitata were 100 mg/L and 34 mg/L, respectively.
QSAR data
The model predicted LC50 for short-term toxicity to fish to range from 11.4 mg/L to 623 mg/L.
The model predicted chronic value for long-term toxicity to fish to range from 1.22 mg/L to 51.5 mg/L.
The model predicted EC50 for short-term toxicity to aquatic invertebrates to range from 6.97 mg/L to 307 mg/L.
The model predicted chronic value for long-term toxicity to aquatic invertebrates to range from 0.834 mg/L - 19.9 mg/L.
The model predicted EC50 for short-term toxicity to aquatic algae and cyanobacteria to range from 7.04 mg/L to 124 mg/L, whereas the chronic value for long-term toxicity to aquatic algae and cyanobacteria was predicted to range from 2.17 mg/L to 23.5 mg/L.
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