Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

HFP may be systemically absorbed via the inhalation route. Based on its volatility and solubility, most of the absorbed HFP would likely be eliminated unchanged following inhalation. Metabolism of some of the systemically absorbed HFP is likely relevant to the observed nephrotoxicity associated with HFP. The results indicated that hexafluoropropene is metabolized to two different GSH-conjugates in rat liver and kidney. The data also strongly suggested that hexafluoropropene metabolites formed in the liver and eliminated with bile are not translocated to the kidney and that intrarenal bioactivation by GSH-conjugation may be responsible for hexafluoropropene-induced nephrotoxicity.