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EC number: 253-575-7 | CAS number: 37640-57-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Similar to OECD testing guideline with fewer reporting details
Data source
Reference
- Reference Type:
- publication
- Title:
- Absence of mutagenic activity for monosodium cyanurate
- Author:
- Hammond, B. G. Barbee, S. J. Wheeler, A. G. Cascieri, T.
- Year:
- 1 985
- Bibliographic source:
- Fundam. Appl. Toxicol. 5: 655-664 (1985)
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
- Deviations:
- yes
- Remarks:
- limited reporting details; only 50 metaphases scored per animals (but two concentrations above limit concentrations tested), no historical control data given
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- sodium;1,3-diaza-5-azanidacyclohexane-2,4,6-trione
- Cas Number:
- 2624-17-1
- IUPAC Name:
- sodium;1,3-diaza-5-azanidacyclohexane-2,4,6-trione
- Details on test material:
- - name in publication: monosodium cyanurate
- supplier: Monsanto company
- composition: 77% cyanurate, 13% sodium and 10% water
- solubility in water: 0.7% w/v
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Simonsen Laboratories, Gilroy, California (USA)
- Weight at study initiation: 160 - 210 g
- Assigned to test groups randomly: yes
- Fasting period before study: 24h
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
no data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- The test item was given as a suspension in 4% Carboxymethylcellulose in water.
- Details on exposure:
- not reported
- Duration of treatment / exposure:
- once
- Frequency of treatment:
- single
- Post exposure period:
- sacrife 24h and 48h after treatment
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1250, 2500 and 5000 mg/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- Triethylenemelamine (ip, 0.275 mg/kg bw)
Examinations
- Tissues and cell types examined:
- femoral bone marrow cells
- Details of tissue and slide preparation:
- Animals were administered 4 mg/ kg eolchicine 2 hr before sacrifice 24 and 48 hr after dosing.
Bone marrow eelis were collected by needle aspiration of both femurs into Hank's balanced salt solution. The cells were processed to break up fibrin, incubated in 0.075 M KCI at 37°C for 20 minutes and then treated with Carnoy's fixative (3 parts absolute methanol: 1 part g1acial acetic acid).
Slides were stained with Giemsa.
50 metaphases were scored for each animal for chromosome aberrations.
1000 cells were scored for each animal for mitotic index - Evaluation criteria:
- Statistical difference with p< 0.05%
- Statistics:
- Student's t-test (for transformed data)
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
- Additional information on results:
- The polyploidy index was not increased.
Any other information on results incl. tables
24h post dosing
Mean aberrations per cell were 0.08 ± 0.02 for vehicle control, 0.08 ± 0.02 for 1250 mg/kg bw, 0.07 ± 0.02 for 2500 mg/kg bw, 0.05 ± 0.02 for 5000 mg/kg bw and 0.89 ± 0.12 for the positive control
48h post dosing
Mean aberrations per cell were 0.07 ± 0.02 for vehicle control, 0.11 ± 0.02 for 1250 mg/kg bw, 0.12 ± 0.03 for 2500 mg/kg bw, 0.09 ± 0.02 for 5000 mg/kg bw and 2.34 ± 0.7 for the positive control
Values are reported for % abnormal cells, mean gaps per cell, % abnormal cells with chromosome deletions, chromosome exchanges, chromatide deletions, chromatide exchanges, aneuploidy, polyploidy and severe damage
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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