Registration Dossier

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Very little other information than the LD50 value is reported.

Data source

Reference
Reference Type:
publication
Title:
Melamine cyanurate, melamine and cyanuric acid: toxicological characteristics
Author:
Babayan EV and Aleksandryan AV
Year:
1985
Bibliographic source:
Zhurnal Eksperimental Nov Kunicheskoi Meditsiny 25 (4), 345 - 349

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No experimental details available that would allow concluding on similarity to available guidelines.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
No details are given.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
water
Details on dermal exposure:
The aqueous suspension was applied onto shaved skin.
Duration of exposure:
no data
Doses:
1 - 10 g per kg bw
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 525 mg/kg bw
Remarks on result:
other: +/- 158 mg/kg bw
Mortality:
yes

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU