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Toxicological information

Health surveillance data

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Administrative data

Endpoint:
health surveillance data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: non standard investigation

Data source

Reference
Reference Type:
publication
Title:
Determination of melamine and cyanuric acid in human urine by a liquid chromatography tandem mass spectrometry
Author:
Zhang et al
Year:
2010
Bibliographic source:
Journal of Chromatography B, 878, 758–762

Materials and methods

Endpoint addressed:
not applicable
Principles of method if other than guideline:
analytical method development and base urine concentrations in China
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
general
Ethical approval:
other: approved by the Hospital Ethical Committee
Details on study design:
The newly developed analytical methods were successfully applied to the analysis of urine samples collected from 86 infants and
110 adults.

Results and discussion

Any other information on results incl. tables

Table: Number of cases and ratio in concentration range of melamine and cyanuric acid in baby and adult urine.

Conc. range (ng/ml)   <10 10–100 100–1000 1000–10,000 >10,000
Melamine Baby 15 (17.4%) 40 (46.5%) 15 (17.4%) 14 (16.3%) 2 (2.3%)
  Adult 14 (12.7%) 76 (69.1%) 15 (13.6%) 5 (4.5%) 0 (0%)
Cyanuric acid Baby 2 (2.3%) 48 (55.8%) 34 (39.5%) 1 (1.2%) 1 (1.2%)
  Adult 1 (0.9%) 85 (72.3%) 22 (20.0%) 2 (1.8%) 0 (0%)

Applicant's summary and conclusion