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EC number: 253-575-7 | CAS number: 37640-57-6
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Data waiving:
- other justification
- Justification for data waiving:
- the study does not need to be conducted because a long-term aquatic toxicity study on invertebrates is available
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- For the detailed read across justification please refer to the attached pdf file.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other:
- Remarks:
- Frazier
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 2 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other:
- Remarks:
- Adema
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other:
- Remarks:
- LeBlanc
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 4 438 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other:
- Remarks:
- Anderson
Referenceopen allclose all
Description of key information
In accordance with Regulation (EC) No 1907/2006, Annex VII, Section 9.1.1 Column 1, long-term toxicity testing can be considered instead of short-trerm.
There is a high probability that the product is not acutely harmful to aquatic invertebrates.Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 200 mg/L
Additional information
For the component CAS 108 -78 -1(melamine):
The study (Frazier 1988) is the newer of both available studies, following the EPA guideline and GLP, and was therefore selected as more reliable. The results of the other study (Adema 1978) were consistent with those of Frazier 1988.
The 24 h and 48 h LC 50 values were both estimated to be > 1000 mg/L. The 24 and 48 hour EC 50 values were 400 and 200 mg/L respectively. The study from Lightner did not reveal effects relevant for the hazard assessment.
For the component CAS 108 -80 -5 (cyanuric acid):
Two different species have been tested. 48h LC50 (Daphnia magna) >1000 mg (LeBlanc 1978) and 96h LC50 (Mysidopsis bahia) >4000 mg/L (Anderson 2002).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
