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EC number: 253-575-7 | CAS number: 37640-57-6
Biodegradation in water and sediment: simulation tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: simulation testing on ultimate degradation in surface water
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- No.:
- #3
- No.:
- #4
- Endpoint:
- biodegradation in water: sediment simulation testing
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Transformation products:
- not specified
- Remarks:
- The test item is considererd not readily biodegradable and not inherently biodegradable. The test item is considered persistent. Therefore no transformation products are expected.
Referenceopen allclose all
Description of key information
In accordance with 1907/2006 (EC) Annex XI there are general rules for adaption of the standard testing regime set out in Annexes VII to X. These requirements are met for the test item by several points, namely section 1.1 “use of existing data”, section 1.2 “weight of evidence” and section 1.3 “Qualitative or Quantitative structure-activity relationship ((Q)SAR)”.
Summary
The test item is insoluble in water. Only mono constituents of melamine or cyanuric acid could be removed from the crystal lattice and become bioavailable. The degradation for both constituents are well known and described. Melamine gets deaminated by adapted bacteria to ammeline, further to ammelide and finally to cyanuric acid. Cyanuric acid then gets decarboxylated to biuret which gets hydrolysed to urea which finally leads to NH3 and CO2. It has to be mentioned that deamination requires adapted microorganisms who are using melamine and the metabolites as a nitrogen source.
Table 1: Summary of the PBT/vPvB properties of the raw materials and the proposed degradation products according to their disseminated REACh dossiers and QSAR estimation.
Substance | P (vP) | B (vB) | T | Conclusion |
Melamine (CAS 108-78-1) | Persistent (P, vP) | Not B, not vB | Repr. 2 | Neither PBT nor vPvB |
Cyanuric acid (CAS 108-80-5) | Persistent (P, vP) | Not B, not vB* | Not classified+ | Neither PBT nor vPvB |
Ammeline (CAS 645-92-1) | Persistent (P, vP)* | Not B, not vB* | Not classified+ | Neither PBT nor vPvB |
Ammelide (CAS 645-93-2) | Persistent (P, vP)* | Not B, not vB* | Not classified+ | Neither PBT nor vPvB |
Biuret (CAS 108-19-0) | Ready biodegradable, not vP* | Not B, not vB* | Not classified+ | Neither PBT nor vPvB |
Key value for chemical safety assessment
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